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Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

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  • Joseph Bondy-Denomy

    (University of Toronto
    †Present address: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94158, USA.)

  • Bianca Garcia

    (University of Toronto)

  • Scott Strum

    (University of Toronto)

  • Mingjian Du

    (University of Toronto)

  • MaryClare F. Rollins

    (Montana State University)

  • Yurima Hidalgo-Reyes

    (University of Toronto)

  • Blake Wiedenheft

    (Montana State University)

  • Karen L. Maxwell

    (Donnelly Centre for Cellular and Biomolecular Research, University of Toronto)

  • Alan R. Davidson

    (University of Toronto
    University of Toronto)

Abstract

Bacterial cells evolved an immune system known as CRISPR–Cas to protect themselves from viral infection, triggering viruses to evolve anti-CRISPR proteins; here, three anti-CRISPR proteins are characterized, with each one interfering with the host CRISPR system at a different point.

Suggested Citation

  • Joseph Bondy-Denomy & Bianca Garcia & Scott Strum & Mingjian Du & MaryClare F. Rollins & Yurima Hidalgo-Reyes & Blake Wiedenheft & Karen L. Maxwell & Alan R. Davidson, 2015. "Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins," Nature, Nature, vol. 526(7571), pages 136-139, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15254
    DOI: 10.1038/nature15254
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    Cited by:

    1. Yanan Zhao & Jiaojiao Hu & Shan-Shan Yang & Jing Zhong & Jianping Liu & Shuo Wang & Yuzhuo Jiao & Fang Jiang & Ruiyang Zhai & Bingnan Ren & Hua Cong & Yuwei Zhu & Fengtong Han & Jixian Zhang & Yue Xu , 2022. "A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Mingfang Bi & Wenjing Su & Jiafu Li & Xiaobing Mo, 2024. "Insights into the inhibition of protospacer integration via direct interaction between Cas2 and AcrVA5," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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