IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v525y2015i7570d10.1038_nature14978.html
   My bibliography  Save this article

Cell-fate determination by ubiquitin-dependent regulation of translation

Author

Listed:
  • Achim Werner

    (Howard Hughes Medical Institute, University of California
    University of California)

  • Shintaro Iwasaki

    (University of California)

  • Colleen A. McGourty

    (University of California)

  • Sofia Medina-Ruiz

    (University of California)

  • Nia Teerikorpi

    (Howard Hughes Medical Institute, University of California
    University of California)

  • Indro Fedrigo

    (University of California)

  • Nicholas T. Ingolia

    (University of California)

  • Michael Rape

    (Howard Hughes Medical Institute, University of California
    University of California)

Abstract

This study shows that a vertebrate-specific ubiquitin ligase modulates neural crest specification in Xenopus development and human embryonic stem-cell differentiation; a proteomics approach reveals that the CUL3KBTBD8 ligase modulates translation by targeting the modulators of ribosomes production NOLC1 and its paralogue TCOF1, which is mutated in a neural-crest-associated syndrome.

Suggested Citation

  • Achim Werner & Shintaro Iwasaki & Colleen A. McGourty & Sofia Medina-Ruiz & Nia Teerikorpi & Indro Fedrigo & Nicholas T. Ingolia & Michael Rape, 2015. "Cell-fate determination by ubiquitin-dependent regulation of translation," Nature, Nature, vol. 525(7570), pages 523-527, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7570:d:10.1038_nature14978
    DOI: 10.1038/nature14978
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14978
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14978?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Anthony J. Asmar & Shaun R. Abrams & Jenny Hsin & Jason C. Collins & Rita M. Yazejian & Youmei Wu & Jean Cho & Andrew D. Doyle & Samhitha Cinthala & Marleen Simon & Richard H. Jaarsveld & David B. Bec, 2023. "A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Kathiresan Selvam & Smitha Sivapragasam & Gregory M. K. Poon & John J. Wyrick, 2023. "Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Alla D. Fedorova & Stephen J. Kiniry & Dmitry E. Andreev & Jonathan M. Mudge & Pavel V. Baranov, 2022. "Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:525:y:2015:i:7570:d:10.1038_nature14978. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.