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Cell-fate determination by ubiquitin-dependent regulation of translation

Author

Listed:
  • Achim Werner

    (Howard Hughes Medical Institute, University of California
    University of California)

  • Shintaro Iwasaki

    (University of California)

  • Colleen A. McGourty

    (University of California)

  • Sofia Medina-Ruiz

    (University of California)

  • Nia Teerikorpi

    (Howard Hughes Medical Institute, University of California
    University of California)

  • Indro Fedrigo

    (University of California)

  • Nicholas T. Ingolia

    (University of California)

  • Michael Rape

    (Howard Hughes Medical Institute, University of California
    University of California)

Abstract

This study shows that a vertebrate-specific ubiquitin ligase modulates neural crest specification in Xenopus development and human embryonic stem-cell differentiation; a proteomics approach reveals that the CUL3KBTBD8 ligase modulates translation by targeting the modulators of ribosomes production NOLC1 and its paralogue TCOF1, which is mutated in a neural-crest-associated syndrome.

Suggested Citation

  • Achim Werner & Shintaro Iwasaki & Colleen A. McGourty & Sofia Medina-Ruiz & Nia Teerikorpi & Indro Fedrigo & Nicholas T. Ingolia & Michael Rape, 2015. "Cell-fate determination by ubiquitin-dependent regulation of translation," Nature, Nature, vol. 525(7570), pages 523-527, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7570:d:10.1038_nature14978
    DOI: 10.1038/nature14978
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    Cited by:

    1. Kathiresan Selvam & Smitha Sivapragasam & Gregory M. K. Poon & John J. Wyrick, 2023. "Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Anthony J. Asmar & Shaun R. Abrams & Jenny Hsin & Jason C. Collins & Rita M. Yazejian & Youmei Wu & Jean Cho & Andrew D. Doyle & Samhitha Cinthala & Marleen Simon & Richard H. Jaarsveld & David B. Bec, 2023. "A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Alla D. Fedorova & Stephen J. Kiniry & Dmitry E. Andreev & Jonathan M. Mudge & Pavel V. Baranov, 2022. "Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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