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Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

Author

Listed:
  • Stéphane Prost

    (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI))

  • Francis Relouzat

    (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI))

  • Marc Spentchian

    (Hôpital Mignot)

  • Yasmine Ouzegdouh

    (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI))

  • Joseph Saliba

    (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI))

  • Gérald Massonnet

    (Unité de Biologie Cellulaire, UMR-S-940 Institut Universitaire d'Hématologie, Hôpital Saint Louis)

  • Jean-Paul Beressi

    (Service d’Endocrinologie et de Diabétologie, Hôpital Mignot)

  • Els Verhoeyen

    (CIRI, International Center for Infectiology Research, EVIR team, Inserm, U1111, CNRS, UMR5308, Université de Lyon-1, ENS de Lyon
    Inserm, U895, Centre de Médecine Moléculaire (C3M), équipe 3)

  • Victoria Raggueneau

    (Laboratoire d’hématologie, Centre Hospitalier de Versailles)

  • Benjamin Maneglier

    (Unité de Pharmacologie, Service de Biologie Médicale, Centre Hospitalier de Versailles)

  • Sylvie Castaigne

    (Service d’Hématologie et d’Oncologie, Hôpital Mignot, Université Versailles Saint-Quentin-en-Yvelines)

  • Christine Chomienne

    (Unité de Biologie Cellulaire, UMR-S-940 Institut Universitaire d'Hématologie, Hôpital Saint Louis)

  • Stany Chrétien

    (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI)
    Inserm, Institute of Emerging Diseases and Innovative Therapies (iMETI))

  • Philippe Rousselot

    (Unité de Biologie Cellulaire, UMR-S-940 Institut Universitaire d'Hématologie, Hôpital Saint Louis
    Service d’Hématologie et d’Oncologie, Hôpital Mignot, Université Versailles Saint-Quentin-en-Yvelines)

  • Philippe Leboulch

    (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI)
    Brigham & Women’s Hospital and Harvard Medical School
    Ramathibodi Hospital and Mahidol University)

Abstract

Although imatinib gives good clinical results in chronic myeloid leukaemia (CML), residual disease attributed to quiescent CML stem cells remains in many patients; here glitazones are shown to reduce the pool of CML stem cells and achieve lasting disease eradication in CML patients in combination with imatinib.

Suggested Citation

  • Stéphane Prost & Francis Relouzat & Marc Spentchian & Yasmine Ouzegdouh & Joseph Saliba & Gérald Massonnet & Jean-Paul Beressi & Els Verhoeyen & Victoria Raggueneau & Benjamin Maneglier & Sylvie Casta, 2015. "Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists," Nature, Nature, vol. 525(7569), pages 380-383, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7569:d:10.1038_nature15248
    DOI: 10.1038/nature15248
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