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The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Author

Listed:
  • Tiffany Y.-T. Hsu

    (Baylor College of Medicine
    Baylor College of Medicine
    Medical Scientist Training Program, Baylor College of Medicine
    Baylor College of Medicine)

  • Lukas M. Simon

    (Baylor College of Medicine)

  • Nicholas J. Neill

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Richard Marcotte

    (Princess Margaret Cancer Centre, University Health Network)

  • Azin Sayad

    (Princess Margaret Cancer Centre, University Health Network)

  • Christopher S. Bland

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Gloria V. Echeverria

    (Baylor College of Medicine
    Baylor College of Medicine
    Baylor College of Medicine)

  • Tingting Sun

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Sarah J. Kurley

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Siddhartha Tyagi

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Kristen L. Karlin

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Rocio Dominguez-Vidaña

    (Baylor College of Medicine
    Baylor College of Medicine
    Baylor College of Medicine)

  • Jessica D. Hartman

    (Baylor College of Medicine
    *Present address: Humacyte, Morrisville, North Carolina 27560, USA.)

  • Alexander Renwick

    (Baylor College of Medicine)

  • Kathleen Scorsone

    (Baylor College of Medicine)

  • Ronald J. Bernardi

    (Baylor College of Medicine)

  • Samuel O. Skinner

    (Baylor College of Medicine
    University of Illinois)

  • Antrix Jain

    (Baylor College of Medicine)

  • Mayra Orellana

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Chandraiah Lagisetti

    (Center for Chemical Biology, SRI International)

  • Ido Golding

    (Baylor College of Medicine
    University of Illinois)

  • Sung Y. Jung

    (Baylor College of Medicine)

  • Joel R. Neilson

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Xiang H.-F. Zhang

    (The Lester and Sue Smith Breast Center, Baylor College of Medicine)

  • Thomas A. Cooper

    (Baylor College of Medicine
    Baylor College of Medicine
    Baylor College of Medicine)

  • Thomas R. Webb

    (Center for Chemical Biology, SRI International)

  • Benjamin G. Neel

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

  • Chad A. Shaw

    (Baylor College of Medicine)

  • Thomas F. Westbrook

    (Baylor College of Medicine
    Baylor College of Medicine
    Baylor College of Medicine)

Abstract

Splicing factors such as BUD31 are identified in a synthetic-lethal screen with cells overexpressing the transcription factor MYC; oncogenic MYC leads to an increase in pre-mRNA synthesis, and spliceosome inhibition impairs the growth and tumorigenicity of MYC-dependent breast cancers, suggesting that spliceosome components may be potential therapeutic targets for MYC-driven cancers.

Suggested Citation

  • Tiffany Y.-T. Hsu & Lukas M. Simon & Nicholas J. Neill & Richard Marcotte & Azin Sayad & Christopher S. Bland & Gloria V. Echeverria & Tingting Sun & Sarah J. Kurley & Siddhartha Tyagi & Kristen L. Ka, 2015. "The spliceosome is a therapeutic vulnerability in MYC-driven cancer," Nature, Nature, vol. 525(7569), pages 384-388, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7569:d:10.1038_nature14985
    DOI: 10.1038/nature14985
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