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Crystal structure of the dynamin tetramer

Author

Listed:
  • Thomas F. Reubold

    (Institut für Biophysikalische Chemie, Medizinische Hochschule Hannover)

  • Katja Faelber

    (Max-Delbrück-Centrum für Molekulare Medizin, Kristallographie)

  • Nuria Plattner

    (Institut für Mathematik, Freie Universität Berlin)

  • York Posor

    (Leibniz-Institut für Molekulare Pharmakologie
    †Present address: Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK.)

  • Katharina Ketel

    (Leibniz-Institut für Molekulare Pharmakologie)

  • Ute Curth

    (Institut für Biophysikalische Chemie, Medizinische Hochschule Hannover
    Forschungseinrichtung Strukturanalyse, Medizinische Hochschule Hannover)

  • Jeanette Schlegel

    (Max-Delbrück-Centrum für Molekulare Medizin, Kristallographie)

  • Roopsee Anand

    (Institut für Biophysikalische Chemie, Medizinische Hochschule Hannover)

  • Dietmar J. Manstein

    (Institut für Biophysikalische Chemie, Medizinische Hochschule Hannover
    Forschungseinrichtung Strukturanalyse, Medizinische Hochschule Hannover)

  • Frank Noé

    (Institut für Mathematik, Freie Universität Berlin)

  • Volker Haucke

    (Leibniz-Institut für Molekulare Pharmakologie
    Institut für Chemie und Biochemie, Freie Universität Berlin)

  • Oliver Daumke

    (Max-Delbrück-Centrum für Molekulare Medizin, Kristallographie
    Institut für Chemie und Biochemie, Freie Universität Berlin)

  • Susanne Eschenburg

    (Institut für Biophysikalische Chemie, Medizinische Hochschule Hannover)

Abstract

The crystal structure of the large GTPase dynamin tetramer is presented, suggesting a mechanism by which oligomerization of dynamin is regulated, and revealing how mutations that interfere with tetramer formation and autoinhibition are of relevance to understanding the congenital muscle disorders Charcot–Marie–Tooth neuropathy and centronuclear myopathy.

Suggested Citation

  • Thomas F. Reubold & Katja Faelber & Nuria Plattner & York Posor & Katharina Ketel & Ute Curth & Jeanette Schlegel & Roopsee Anand & Dietmar J. Manstein & Frank Noé & Volker Haucke & Oliver Daumke & Su, 2015. "Crystal structure of the dynamin tetramer," Nature, Nature, vol. 525(7569), pages 404-408, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7569:d:10.1038_nature14880
    DOI: 10.1038/nature14880
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    Cited by:

    1. Lucas Gewehr & Benedikt Junglas & Ruven Jilly & Johannes Franz & Wenyu Eva Zhu & Tobias Weidner & Mischa Bonn & Carsten Sachse & Dirk Schneider, 2023. "SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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