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Replisome speed determines the efficiency of the Tus−Ter replication termination barrier

Author

Listed:
  • Mohamed M. Elshenawy

    (King Abdullah University of Science and Technology)

  • Slobodan Jergic

    (Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong)

  • Zhi-Qiang Xu

    (Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong)

  • Mohamed A. Sobhy

    (King Abdullah University of Science and Technology)

  • Masateru Takahashi

    (King Abdullah University of Science and Technology)

  • Aaron J. Oakley

    (Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong)

  • Nicholas E. Dixon

    (Centre for Medical & Molecular Bioscience, Illawarra Health & Medical Research Institute and University of Wollongong)

  • Samir M. Hamdan

    (King Abdullah University of Science and Technology)

Abstract

The Tus–Ter termination site of Escherichia coli is not completely efficient in stopping DNA replication, with about half of replisomes bypassing this blockade; here the speed of the replication machinery is shown to determine the outcome of the encounter between the replisome and Tus–Ter.

Suggested Citation

  • Mohamed M. Elshenawy & Slobodan Jergic & Zhi-Qiang Xu & Mohamed A. Sobhy & Masateru Takahashi & Aaron J. Oakley & Nicholas E. Dixon & Samir M. Hamdan, 2015. "Replisome speed determines the efficiency of the Tus−Ter replication termination barrier," Nature, Nature, vol. 525(7569), pages 394-398, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7569:d:10.1038_nature14866
    DOI: 10.1038/nature14866
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    Cited by:

    1. Ehsan Akbari & Melika Shahhosseini & Ariel Robbins & Michael G. Poirier & Jonathan W. Song & Carlos E. Castro, 2022. "Low cost and massively parallel force spectroscopy with fluid loading on a chip," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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