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Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

Author

Listed:
  • Zane Jaunmuktane

    (The National Hospital for Neurology and Neurosurgery)

  • Simon Mead

    (Medical Research Council Prion Unit
    UCL Institute of Neurology
    National Prion Clinic, The National Hospital for Neurology and Neurosurgery)

  • Matthew Ellis

    (UCL Institute of Neurology)

  • Jonathan D. F. Wadsworth

    (Medical Research Council Prion Unit
    UCL Institute of Neurology)

  • Andrew J. Nicoll

    (Medical Research Council Prion Unit
    UCL Institute of Neurology)

  • Joanna Kenny

    (Medical Research Council Prion Unit
    National Prion Clinic, The National Hospital for Neurology and Neurosurgery)

  • Francesca Launchbury

    (UCL Institute of Neurology)

  • Jacqueline Linehan

    (Medical Research Council Prion Unit)

  • Angela Richard-Loendt

    (UCL Institute of Neurology)

  • A. Sarah Walker

    (MRC Clinical Trials Unit at University College London)

  • Peter Rudge

    (Medical Research Council Prion Unit
    National Prion Clinic, The National Hospital for Neurology and Neurosurgery)

  • John Collinge

    (Medical Research Council Prion Unit
    UCL Institute of Neurology
    National Prion Clinic, The National Hospital for Neurology and Neurosurgery)

  • Sebastian Brandner

    (The National Hospital for Neurology and Neurosurgery
    Medical Research Council Prion Unit
    UCL Institute of Neurology)

Abstract

Treatment of children with human cadaver-derived growth hormone (c-hGH) contaminated with prions resulted in transmission of Creutzfeldt–Jakob disease (CJD); unexpectedly, in an autopsy study of eight such iCJD patients, the authors found amyloid-β deposition in the grey matter typical of that seen in Alzheimer's disease and amyloid-β in the blood vessel walls characteristic of cerebral amyloid angiopathy, consistent with iatrogenic transmission of amyloid-β pathology in addition to CJD and suggests that healthy c-hGH-exposed individuals may also be at risk of Alzheimer's disease and cerebral amyloid angiopathy.

Suggested Citation

  • Zane Jaunmuktane & Simon Mead & Matthew Ellis & Jonathan D. F. Wadsworth & Andrew J. Nicoll & Joanna Kenny & Francesca Launchbury & Jacqueline Linehan & Angela Richard-Loendt & A. Sarah Walker & Peter, 2015. "Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy," Nature, Nature, vol. 525(7568), pages 247-250, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7568:d:10.1038_nature15369
    DOI: 10.1038/nature15369
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