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Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

Author

Listed:
  • Xin Ye

    (Whitehead Institute for Biomedical Research)

  • Wai Leong Tam

    (Whitehead Institute for Biomedical Research
    Genome Institute of Singapore
    Cancer Science Institute of Singapore)

  • Tsukasa Shibue

    (Whitehead Institute for Biomedical Research)

  • Yasemin Kaygusuz

    (Whitehead Institute for Biomedical Research)

  • Ferenc Reinhardt

    (Whitehead Institute for Biomedical Research)

  • Elinor Ng Eaton

    (Whitehead Institute for Biomedical Research)

  • Robert A. Weinberg

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology
    Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology)

Abstract

This study finds that the epithelial-to-mesenchymal (EMT) transition program, which is common to both mammary gland reconstituting stem cells and mammary tumour-initiating cells, is differentially regulated by two distinct EMT factors, Slug and Snail; the findings illustrate that although they appear similar, normal tissue stem cells and tumour-initiating cells are controlled by distinct regulatory processes.

Suggested Citation

  • Xin Ye & Wai Leong Tam & Tsukasa Shibue & Yasemin Kaygusuz & Ferenc Reinhardt & Elinor Ng Eaton & Robert A. Weinberg, 2015. "Distinct EMT programs control normal mammary stem cells and tumour-initiating cells," Nature, Nature, vol. 525(7568), pages 256-260, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7568:d:10.1038_nature14897
    DOI: 10.1038/nature14897
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    Cited by:

    1. Mariel C. Paul & Christian Schneeweis & Chiara Falcomatà & Chuan Shan & Daniel Rossmeisl & Stella Koutsouli & Christine Klement & Magdalena Zukowska & Sebastian A. Widholz & Moritz Jesinghaus & Konsta, 2023. "Non-canonical functions of SNAIL drive context-specific cancer progression," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Nastaran Mohammadi Ghahhari & Magdalena K. Sznurkowska & Nicolas Hulo & Lilia Bernasconi & Nicola Aceto & Didier Picard, 2022. "Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Lining Liang & Hao Sun & Wei Zhang & Mengdan Zhang & Xiao Yang & Rui Kuang & Hui Zheng, 2016. "Meta-Analysis of EMT Datasets Reveals Different Types of EMT," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-22, June.

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