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Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

Author

Listed:
  • Junchao Dong

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Rohit A. Panchakshari

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Tingting Zhang

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
    † Present addresses: Eli Lilly and Company, Alexandria Center for Life Sciences, 450 East 29th Street, New York, New York 10016, USA (T.Z.); National Institute of Biological Sciences, Beijing 102206, Beijing, China (Y.Z.); Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA (Y.-J.H.); 121Bio, 700 Main Street, Cambridge, Massachusetts 02139, USA (M.G.).)

  • Yu Zhang

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
    † Present addresses: Eli Lilly and Company, Alexandria Center for Life Sciences, 450 East 29th Street, New York, New York 10016, USA (T.Z.); National Institute of Biological Sciences, Beijing 102206, Beijing, China (Y.Z.); Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA (Y.-J.H.); 121Bio, 700 Main Street, Cambridge, Massachusetts 02139, USA (M.G.).)

  • Jiazhi Hu

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Sabrina A. Volpi

    (Boston Children’s Hospital and Joint Program in Transfusion Medicine, Harvard Medical School)

  • Robin M. Meyers

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Yu-Jui Ho

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
    † Present addresses: Eli Lilly and Company, Alexandria Center for Life Sciences, 450 East 29th Street, New York, New York 10016, USA (T.Z.); National Institute of Biological Sciences, Beijing 102206, Beijing, China (Y.Z.); Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA (Y.-J.H.); 121Bio, 700 Main Street, Cambridge, Massachusetts 02139, USA (M.G.).)

  • Zhou Du

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Davide F. Robbiani

    (Howard Hughes Medical Institute, Laboratory of Molecular Immunology, The Rockefeller University)

  • Feilong Meng

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Monica Gostissa

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
    † Present addresses: Eli Lilly and Company, Alexandria Center for Life Sciences, 450 East 29th Street, New York, New York 10016, USA (T.Z.); National Institute of Biological Sciences, Beijing 102206, Beijing, China (Y.Z.); Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA (Y.-J.H.); 121Bio, 700 Main Street, Cambridge, Massachusetts 02139, USA (M.G.).)

  • Michel C. Nussenzweig

    (Howard Hughes Medical Institute, Laboratory of Molecular Immunology, The Rockefeller University)

  • John P. Manis

    (Boston Children’s Hospital and Joint Program in Transfusion Medicine, Harvard Medical School)

  • Frederick W. Alt

    (Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

Abstract

High-throughput genome-wide sequencing reveals why class switch recombination in the IgH locus, an essential step in the process of antibody generation, has a directional joining bias towards deletion rather than inversion.

Suggested Citation

  • Junchao Dong & Rohit A. Panchakshari & Tingting Zhang & Yu Zhang & Jiazhi Hu & Sabrina A. Volpi & Robin M. Meyers & Yu-Jui Ho & Zhou Du & Davide F. Robbiani & Feilong Meng & Monica Gostissa & Michel C, 2015. "Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching," Nature, Nature, vol. 525(7567), pages 134-139, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7567:d:10.1038_nature14970
    DOI: 10.1038/nature14970
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