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Regulation of mitochondrial morphology and function by stearoylation of TFR1

Author

Listed:
  • Deniz Senyilmaz

    (German Cancer Research Center (DKFZ))

  • Sam Virtue

    (University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science)

  • Xiaojun Xu

    (German Cancer Research Center (DKFZ)
    † Present address: State Key laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, China.)

  • Chong Yew Tan

    (University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science)

  • Julian L. Griffin

    (The Department of Biochemistry)

  • Aubry K. Miller

    (German Cancer Research Center (DKFZ))

  • Antonio Vidal-Puig

    (University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
    Wellcome Trust Sanger Institute)

  • Aurelio A. Teleman

    (German Cancer Research Center (DKFZ))

Abstract

Mitochondria have essential functions within cells, and their dysfunction is linked to various disorders; here, the fatty acid stearic acid (C18:0), which is a dietary component, and the transferrin receptor (TFR1) are shown to regulate mitochondrial function.

Suggested Citation

  • Deniz Senyilmaz & Sam Virtue & Xiaojun Xu & Chong Yew Tan & Julian L. Griffin & Aubry K. Miller & Antonio Vidal-Puig & Aurelio A. Teleman, 2015. "Regulation of mitochondrial morphology and function by stearoylation of TFR1," Nature, Nature, vol. 525(7567), pages 124-128, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7567:d:10.1038_nature14601
    DOI: 10.1038/nature14601
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    Cited by:

    1. Lu Jin & Shuang Han & Xue Lv & Xiaofei Li & Ziyin Zhang & Henry Kuang & Zhimin Chen & Cheng-an Lv & Wei Peng & Zhuoying Yang & Miqi Yang & Lin Mi & Tongyu Liu & Shengshan Ma & Xinyuan Qiu & Qintao Wan, 2023. "The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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