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Structural basis for stop codon recognition in eukaryotes

Author

Listed:
  • Alan Brown

    (MRC Laboratory of Molecular Biology)

  • Sichen Shao

    (MRC Laboratory of Molecular Biology)

  • Jason Murray

    (MRC Laboratory of Molecular Biology)

  • Ramanujan S. Hegde

    (MRC Laboratory of Molecular Biology)

  • V. Ramakrishnan

    (MRC Laboratory of Molecular Biology)

Abstract

All eukaryotes utilize a single termination factor, eRF1, to halt translation when the ribosome encounters one of three possible stop codons; here electron cryo-microscopy structures of ribosome–eRF1 complexes in the process of recognizing each stop codon reveal how stop codons are discriminated from sense codons.

Suggested Citation

  • Alan Brown & Sichen Shao & Jason Murray & Ramanujan S. Hegde & V. Ramakrishnan, 2015. "Structural basis for stop codon recognition in eukaryotes," Nature, Nature, vol. 524(7566), pages 493-496, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7566:d:10.1038_nature14896
    DOI: 10.1038/nature14896
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    Cited by:

    1. Franziska Nadler & Elena Lavdovskaia & Angelique Krempler & Luis Daniel Cruz-Zaragoza & Sven Dennerlein & Ricarda Richter-Dennerlein, 2022. "Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Kotchaphorn Mangkalaphiban & Lianwu Fu & Ming Du & Kari Thrasher & Kim M. Keeling & David M. Bedwell & Allan Jacobson, 2024. "Extended stop codon context predicts nonsense codon readthrough efficiency in human cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Nikhil Bharti & Leonardo Santos & Marcos Davyt & Stine Behrmann & Marie Eichholtz & Alejandro Jimenez-Sanchez & Jeong S. Hong & Andras Rab & Eric J. Sorscher & Suki Albers & Zoya Ignatova, 2024. "Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Ramona Weber & Leon Kleemann & Insa Hirschberg & Min-Yi Chung & Eugene Valkov & Cátia Igreja, 2022. "DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5′ leaders," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Maria Luisa Romero Romero & Jonas Poehls & Anastasiia Kirilenko & Doris Richter & Tobias Jumel & Anna Shevchenko & Agnes Toth-Petroczy, 2024. "Environment modulates protein heterogeneity through transcriptional and translational stop codon readthrough," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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