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A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

Author

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  • Xiaowen Wang

    (State University of New York Upstate Medical University)

  • Xin Jie Chen

    (State University of New York Upstate Medical University)

Abstract

A new pathway of mitochondria-mediated cell death termed mitochondrial precursor over-accumulation stress (mPOS) is identified that could explain the link between mitochondrial dysfunction and misfolding of cytosolic proteins during ageing and disease; the pathway is triggered not only by mutations affecting the core protein import machineries, but also by conditions that interfere with mitochondrial inner membrane integrity and function, and a large network of genes that suppress mPOS in favour of cell survival is also identified.

Suggested Citation

  • Xiaowen Wang & Xin Jie Chen, 2015. "A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death," Nature, Nature, vol. 524(7566), pages 481-484, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7566:d:10.1038_nature14859
    DOI: 10.1038/nature14859
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    Cited by:

    1. Hope I. Needs & Emily Glover & Gonçalo C. Pereira & Alina Witt & Wolfgang Hübner & Mark P. Dodding & Jeremy M. Henley & Ian Collinson, 2024. "Rescue of mitochondrial import failure by intercellular organellar transfer," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Evelyn Fessler & Luisa Krumwiede & Lucas T. Jae, 2022. "DELE1 tracks perturbed protein import and processing in human mitochondria," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Eirini Lionaki & Ilias Gkikas & Ioanna Daskalaki & Maria-Konstantina Ioannidi & Maria I. Klapa & Nektarios Tavernarakis, 2022. "Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Caroline E. Dewar & Silke Oeljeklaus & Jan Mani & Wignand W. D. Mühlhäuser & Corinne Känel & Johannes Zimmermann & Torsten Ochsenreiter & Bettina Warscheid & André Schneider, 2022. "Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Minji Kim & Remigiusz A. Serwa & Lukasz Samluk & Ida Suppanz & Agata Kodroń & Tomasz M. Stępkowski & Praveenraj Elancheliyan & Biniyam Tsegaye & Silke Oeljeklaus & Michal Wasilewski & Bettina Warschei, 2023. "Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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