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Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation

Author

Listed:
  • Nelio T. L. Rodrigues

    (MRC Laboratory for Molecular Cell Biology, University College London)

  • Sergey Lekomtsev

    (MRC Laboratory for Molecular Cell Biology, University College London)

  • Silvana Jananji

    (Sainte-Justine Hospital Research Center)

  • Janos Kriston-Vizi

    (MRC Laboratory for Molecular Cell Biology, University College London)

  • Gilles R. X. Hickson

    (Sainte-Justine Hospital Research Center
    Université de Montréal)

  • Buzz Baum

    (MRC Laboratory for Molecular Cell Biology, University College London
    Institute for the Physics of Living Systems, University College London
    CelTisPhyBio Labex, Institut Curie)

Abstract

A study of division in proliferating animal cells points to the existence of a kinetochore-based signalling pathway, independent of furrow formation, centrosomes and microtubules, that couples chromosome segregation to cell division.

Suggested Citation

  • Nelio T. L. Rodrigues & Sergey Lekomtsev & Silvana Jananji & Janos Kriston-Vizi & Gilles R. X. Hickson & Buzz Baum, 2015. "Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation," Nature, Nature, vol. 524(7566), pages 489-492, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7566:d:10.1038_nature14496
    DOI: 10.1038/nature14496
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