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Propagation of conformational changes during μ-opioid receptor activation

Author

Listed:
  • Rémy Sounier

    (Institut de Genomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Camille Mas

    (Institut de Genomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

  • Jan Steyaert

    (Structural Biology Brussels, Vrije Universiteit Brussel
    Structural Biology Research Center, VIB)

  • Toon Laeremans

    (Structural Biology Brussels, Vrije Universiteit Brussel
    Structural Biology Research Center, VIB)

  • Aashish Manglik

    (Stanford University School of Medicine)

  • Weijiao Huang

    (Stanford University School of Medicine)

  • Brian K. Kobilka

    (Stanford University School of Medicine)

  • Héléne Déméné

    (Centre de Biochimie Structurale, CNRS UMR 5048-INSERM 1054- University of Montpellier)

  • Sébastien Granier

    (Institut de Genomique Fonctionnelle, CNRS UMR-5203 INSERM U1191, University of Montpellier)

Abstract

NMR spectroscopy reveals the conformational changes of the μ-opioid receptor that are associated with receptor activation, helping to explain why the allosteric coupling between the agonist-binding pocket and the cytoplasmic G-protein-coupling interface of this receptor is relatively weak.

Suggested Citation

  • Rémy Sounier & Camille Mas & Jan Steyaert & Toon Laeremans & Aashish Manglik & Weijiao Huang & Brian K. Kobilka & Héléne Déméné & Sébastien Granier, 2015. "Propagation of conformational changes during μ-opioid receptor activation," Nature, Nature, vol. 524(7565), pages 375-378, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7565:d:10.1038_nature14680
    DOI: 10.1038/nature14680
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    Cited by:

    1. Chris Habrian & Naomi Latorraca & Zhu Fu & Ehud Y. Isacoff, 2023. "Homo- and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Minfei Su & Navid Paknejad & Lan Zhu & Jinan Wang & Hung Nguyen Do & Yinglong Miao & Wei Liu & Richard K. Hite & Xin-Yun Huang, 2022. "Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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