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The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia

Author

Listed:
  • Lan Zhao

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Eduardo Oliver

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Klio Maratou

    (Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital)

  • Santosh S. Atanur

    (Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital)

  • Olivier D. Dubois

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Emanuele Cotroneo

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Chien-Nien Chen

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Lei Wang

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Cristina Arce

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

  • Pauline L. Chabosseau

    (Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital)

  • Joan Ponsa-Cobas

    (Section of Epigenomics and Disease, Faculty of Medicine, Imperial College London, Hammersmith Hospital)

  • Maria G. Frid

    (University of Colorado Denver)

  • Benjamin Moyon

    (Transgenics and Embryonic Stem Cell Laboratory, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital)

  • Zoe Webster

    (Transgenics and Embryonic Stem Cell Laboratory, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital)

  • Almaz Aldashev

    (Institute of Molecular Biology and Medicine)

  • Jorge Ferrer

    (Section of Epigenomics and Disease, Faculty of Medicine, Imperial College London, Hammersmith Hospital)

  • Guy A. Rutter

    (Section of Cell Biology and Functional Genomics, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital)

  • Kurt R. Stenmark

    (University of Colorado Denver)

  • Timothy J. Aitman

    (Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital
    †Present address: Centre for Genomic and Experimental Medicine, Institute of Genetic and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK)

  • Martin R. Wilkins

    (Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital)

Abstract

Zinc transporter ZIP12 expression is increased in many cell types in remodelled mammalian pulmonary arterioles in hypoxia-induced pulmonary hypertension.

Suggested Citation

  • Lan Zhao & Eduardo Oliver & Klio Maratou & Santosh S. Atanur & Olivier D. Dubois & Emanuele Cotroneo & Chien-Nien Chen & Lei Wang & Cristina Arce & Pauline L. Chabosseau & Joan Ponsa-Cobas & Maria G. , 2015. "The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia," Nature, Nature, vol. 524(7565), pages 356-360, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7565:d:10.1038_nature14620
    DOI: 10.1038/nature14620
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    Citations

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    Cited by:

    1. Yao Zhang & Yuhan Jiang & Kaifu Gao & Dexin Sui & Peixuan Yu & Min Su & Guo-Wei Wei & Jian Hu, 2023. "Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yao Zhang & Majid Jafari & Tuo Zhang & Dexin Sui & Luca Sagresti & Kenneth M. Merz & Jian Hu, 2024. "Molecular insights into substrate translocation in an elevator-type metal transporter," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Changxu Pang & Jin Chai & Ping Zhu & John Shanklin & Qun Liu, 2023. "Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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