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Genetic compensation induced by deleterious mutations but not gene knockdowns

Author

Listed:
  • Andrea Rossi

    (Max Planck Institute for Heart and Lung Research)

  • Zacharias Kontarakis

    (Max Planck Institute for Heart and Lung Research)

  • Claudia Gerri

    (Max Planck Institute for Heart and Lung Research)

  • Hendrik Nolte

    (Max Planck Institute for Heart and Lung Research
    † Present address: Institute for Genetics and CECAD, University of Cologne, 50931 Cologne, Germany)

  • Soraya Hölper

    (Max Planck Institute for Heart and Lung Research)

  • Marcus Krüger

    (Max Planck Institute for Heart and Lung Research
    † Present address: Institute for Genetics and CECAD, University of Cologne, 50931 Cologne, Germany)

  • Didier Y. R. Stainier

    (Max Planck Institute for Heart and Lung Research)

Abstract

Zebrafish embryos injected with egfl7 morpholino exhibit severe vascular defects but egfl7 mutants do not show any obvious phenotypes, illustrating the power of comparing mutants and morphants to identify modifier genes.

Suggested Citation

  • Andrea Rossi & Zacharias Kontarakis & Claudia Gerri & Hendrik Nolte & Soraya Hölper & Marcus Krüger & Didier Y. R. Stainier, 2015. "Genetic compensation induced by deleterious mutations but not gene knockdowns," Nature, Nature, vol. 524(7564), pages 230-233, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7564:d:10.1038_nature14580
    DOI: 10.1038/nature14580
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    Citations

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    Cited by:

    1. Juqi Zou & Satoshi Anai & Satoshi Ota & Shizuka Ishitani & Masayuki Oginuma & Tohru Ishitani, 2023. "Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Paul W. Chrystal & Nils J. Lambacher & Lance P. Doucette & James Bellingham & Elena R. Schiff & Nicole C. L. Noel & Chunmei Li & Sofia Tsiropoulou & Geoffrey A. Casey & Yi Zhai & Nathan J. Nadolski & , 2022. "The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. Valentina Cigliola & Adam Shoffner & Nutishia Lee & Jianhong Ou & Trevor J. Gonzalez & Jiaul Hoque & Clayton J. Becker & Yanchao Han & Grace Shen & Timothy D. Faw & Muhammad M. Abd-El-Barr & Shyni Var, 2023. "Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Karthika Devi Kiran Kumar & Shubhangi Singh & Stella Maria Schmelzle & Paul Vogel & Carolin Fruhner & Alfred Hanswillemenke & Adrian Brun & Jacqueline Wettengel & Yvonne Füll & Lukas Funk & Valentin M, 2024. "An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Jingying Chen & Jing Ding & Yongyu Li & Fujuan Feng & Yuhang Xu & Tao Wang & Jianbo He & Jing Cang & Lingfei Luo, 2024. "Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Lee B. Miles & Vanessa Calcinotto & Sara Oveissi & Rita J. Serrano & Carmen Sonntag & Orlen Mulia & Clara Lee & Robert J. Bryson-Richardson, 2024. "CRIMP: a CRISPR/Cas9 insertional mutagenesis protocol and toolkit," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    7. Federica Diofano & Karolina Weinmann & Isabelle Schneider & Kevin D Thiessen & Wolfgang Rottbauer & Steffen Just, 2020. "Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency," PLOS Genetics, Public Library of Science, vol. 16(11), pages 1-24, November.

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