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X-ray structure of a mammalian stearoyl-CoA desaturase

Author

Listed:
  • Yonghong Bai

    (Baylor College of Medicine)

  • Jason G. McCoy

    (Baylor College of Medicine)

  • Elena J. Levin

    (Baylor College of Medicine)

  • Pablo Sobrado

    (University of Wisconsin–Madison)

  • Kanagalaghatta R. Rajashankar

    (Cornell University, Argonne National Laboratory)

  • Brian G. Fox

    (University of Wisconsin–Madison)

  • Ming Zhou

    (Baylor College of Medicine)

Abstract

The crystal structure of mouse SCD1 bound to fatty acid stearoyl-CoA is solved at 2.6 Å resolution; the structure reveals a novel geometry for the dimetal centre, and the acyl chain of the bound fatty acid is shown to be shielded and shaped to a particular conformation by the enzyme, providing a structural basis for the selectivity of fatty acid metabolism.

Suggested Citation

  • Yonghong Bai & Jason G. McCoy & Elena J. Levin & Pablo Sobrado & Kanagalaghatta R. Rajashankar & Brian G. Fox & Ming Zhou, 2015. "X-ray structure of a mammalian stearoyl-CoA desaturase," Nature, Nature, vol. 524(7564), pages 252-256, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7564:d:10.1038_nature14549
    DOI: 10.1038/nature14549
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    Cited by:

    1. Lie Wang & Ming Zhou, 2023. "Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Xue Guo & Jianxiu Zhang & Lei Han & Juliet Lee & Shoshana C. Williams & Allison Forsberg & Yan Xu & Rachel Narehood Austin & Liang Feng, 2023. "Structure and mechanism of the alkane-oxidizing enzyme AlkB," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Maria Thürmer & André Gollowitzer & Helmut Pein & Konstantin Neukirch & Elif Gelmez & Lorenz Waltl & Natalie Wielsch & René Winkler & Konstantin Löser & Julia Grander & Madlen Hotze & Sönke Harder & A, 2022. "PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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