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Conversion of amides to esters by the nickel-catalysed activation of amide C–N bonds

Author

Listed:
  • Liana Hie

    (University of California)

  • Noah F. Fine Nathel

    (University of California)

  • Tejas K. Shah

    (University of California)

  • Emma L. Baker

    (University of California)

  • Xin Hong

    (University of California)

  • Yun-Fang Yang

    (University of California)

  • Peng Liu

    (University of California)

  • K. N. Houk

    (University of California)

  • Neil K. Garg

    (University of California)

Abstract

Although enzymes are able to cleave amide bonds in nature, it is difficult to selectively break the carbon–nitrogen bond of an amide using synthetic chemistry; now the activation and cleavage of these bonds using nickel catalysts is used to convert amides to esters.

Suggested Citation

  • Liana Hie & Noah F. Fine Nathel & Tejas K. Shah & Emma L. Baker & Xin Hong & Yun-Fang Yang & Peng Liu & K. N. Houk & Neil K. Garg, 2015. "Conversion of amides to esters by the nickel-catalysed activation of amide C–N bonds," Nature, Nature, vol. 524(7563), pages 79-83, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7563:d:10.1038_nature14615
    DOI: 10.1038/nature14615
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    Cited by:

    1. Hongyu Zhong & Dominic T. Egger & Valentina C. M. Gasser & Patrick Finkelstein & Loris Keim & Merlin Z. Seidel & Nils Trapp & Bill Morandi, 2023. "Skeletal metalation of lactams through a carbonyl-to-nickel-exchange logic," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Yuxing Cai & Yuxin Zhao & Kai Tang & Hong Zhang & Xueling Mo & Jiean Chen & Yong Huang, 2024. "Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene," Nature Communications, Nature, vol. 15(1), pages 1-7, December.

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