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Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

Author

Listed:
  • Yi-Gang Tong

    (State Key Laboratory of Pathogen and Biosecurity)

  • Wei-Feng Shi

    (Institute of Pathogen Biology, Taishan Medical College)

  • Di Liu

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Jun Qian

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Long Liang

    (State Key Laboratory of Pathogen and Biosecurity)

  • Xiao-Chen Bo

    (Beijing Key Laboratory of New Molecular Diagnostics Technology)

  • Jun Liu

    (Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention)

  • Hong-Guang Ren

    (State Key Laboratory of Pathogen and Biosecurity)

  • Hang Fan

    (State Key Laboratory of Pathogen and Biosecurity)

  • Ming Ni

    (Beijing Key Laboratory of New Molecular Diagnostics Technology)

  • Yang Sun

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Yuan Jin

    (State Key Laboratory of Pathogen and Biosecurity)

  • Yue Teng

    (State Key Laboratory of Pathogen and Biosecurity)

  • Zhen Li

    (Beijing Key Laboratory of New Molecular Diagnostics Technology)

  • David Kargbo

    (Sierra Leone Ministry of Health and Sanitation)

  • Foday Dafae

    (Sierra Leone Ministry of Health and Sanitation)

  • Alex Kanu

    (Sierra Leone-China Friendship Hospital)

  • Cheng-Chao Chen

    (BGI-Shenzhen)

  • Zhi-Heng Lan

    (BGI-Shenzhen)

  • Hui Jiang

    (BGI-Shenzhen)

  • Yang Luo

    (Wellcome Trust Sanger Institute)

  • Hui-Jun Lu

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Xiao-Guang Zhang

    (Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention)

  • Fan Yang

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Yi Hu

    (State Key Laboratory of Pathogen and Biosecurity)

  • Yu-Xi Cao

    (Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention)

  • Yong-Qiang Deng

    (State Key Laboratory of Pathogen and Biosecurity)

  • Hao-Xiang Su

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Yu Sun

    (State Key Laboratory of Pathogen and Biosecurity)

  • Wen-Sen Liu

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Zhuang Wang

    (State Key Laboratory of Pathogen and Biosecurity)

  • Cheng-Yu Wang

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Zhao-Yang Bu

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Zhen-Dong Guo

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Liu-Bo Zhang

    (Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention)

  • Wei-Min Nie

    (The No. 302 Hospital)

  • Chang-Qing Bai

    (The No. 307 Hospital)

  • Chun-Hua Sun

    (State Key Laboratory of Pathogen and Biosecurity)

  • Xiao-Ping An

    (State Key Laboratory of Pathogen and Biosecurity)

  • Pei-Song Xu

    (Beijing Key Laboratory of New Molecular Diagnostics Technology)

  • Xiang-Li-Lan Zhang

    (State Key Laboratory of Pathogen and Biosecurity)

  • Yong Huang

    (State Key Laboratory of Pathogen and Biosecurity)

  • Zhi-Qiang Mi

    (State Key Laboratory of Pathogen and Biosecurity)

  • Dong Yu

    (State Key Laboratory of Pathogen and Biosecurity)

  • Hong-Wu Yao

    (State Key Laboratory of Pathogen and Biosecurity)

  • Yong Feng

    (National Health and Family Planning Commission)

  • Zhi-Ping Xia

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Xue-Xing Zheng

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Song-Tao Yang

    (Key Laboratory of Jilin Province for Zoonosis Prevention and Control)

  • Bing Lu

    (State Key Laboratory of Pathogen and Biosecurity)

  • Jia-Fu Jiang

    (State Key Laboratory of Pathogen and Biosecurity)

  • Brima Kargbo

    (Sierra Leone Ministry of Health and Sanitation)

  • Fu-Chu He

    (State Key Laboratory of Proteomics)

  • George F. Gao

    (Institute of Microbiology, Chinese Academy of Sciences
    Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
    Chinese Center for Disease Control and Prevention)

  • Wu-Chun Cao

    (State Key Laboratory of Pathogen and Biosecurity)

Abstract

The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous outbreaks and that the genetic diversity of the virus has increased substantially, with the emergence of several novel lineages.

Suggested Citation

  • Yi-Gang Tong & Wei-Feng Shi & Di Liu & Jun Qian & Long Liang & Xiao-Chen Bo & Jun Liu & Hong-Guang Ren & Hang Fan & Ming Ni & Yang Sun & Yuan Jin & Yue Teng & Zhen Li & David Kargbo & Foday Dafae & Al, 2015. "Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone," Nature, Nature, vol. 524(7563), pages 93-96, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7563:d:10.1038_nature14490
    DOI: 10.1038/nature14490
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    Cited by:

    1. Johndrow, James E. & Palacios, Julia A., 2019. "Exact limits of inference in coalescent models," Theoretical Population Biology, Elsevier, vol. 125(C), pages 75-93.

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