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Lanosterol reverses protein aggregation in cataracts

Author

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  • Ling Zhao

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    †Present address: Institute of Molecular Medicine, Peking University, Beijing 100871, China.)

  • Xiang-Jun Chen

    (State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University)

  • Jie Zhu

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    Xijing Hospital, Fourth Military Medical University)

  • Yi-Bo Xi

    (State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University)

  • Xu Yang

    (BGI-Shenzhen)

  • Li-Dan Hu

    (State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University)

  • Hong Ouyang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Sherrina H. Patel

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Xin Jin

    (BGI-Shenzhen)

  • Danni Lin

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Frances Wu

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Ken Flagg

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Huimin Cai

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    Guangzhou KangRui Biological Pharmaceutical Technology Company)

  • Gen Li

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Guiqun Cao

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Ying Lin

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Daniel Chen

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Cindy Wen

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Christopher Chung

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Yandong Wang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Austin Qiu

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    CapitalBio Genomics Co., Ltd.)

  • Emily Yeh

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Wenqiu Wang

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University)

  • Xun Hu

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Seanna Grob

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Ruben Abagyan

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California)

  • Zhiguang Su

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Harry Christianto Tjondro

    (State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University)

  • Xi-Juan Zhao

    (State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University)

  • Hongrong Luo

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Rui Hou

    (Guangzhou KangRui Biological Pharmaceutical Technology Company)

  • J. Jefferson
  • P. Perry

    (University of California Riverside)

  • Weiwei Gao

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    University of California)

  • Igor Kozak

    (King Khaled Eye Specialist Hospital)

  • David Granet

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego)

  • Yingrui Li

    (BGI-Shenzhen)

  • Xiaodong Sun

    (Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University)

  • Jun Wang

    (BGI-Shenzhen)

  • Liangfang Zhang

    (Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    University of California)

  • Yizhi Liu

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Yong-Bin Yan

    (State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University)

  • Kang Zhang

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego
    University of California)

Abstract

Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which can reduce cataract severity and increase lens transparency in vivo in dogs.

Suggested Citation

  • Ling Zhao & Xiang-Jun Chen & Jie Zhu & Yi-Bo Xi & Xu Yang & Li-Dan Hu & Hong Ouyang & Sherrina H. Patel & Xin Jin & Danni Lin & Frances Wu & Ken Flagg & Huimin Cai & Gen Li & Guiqun Cao & Ying Lin & D, 2015. "Lanosterol reverses protein aggregation in cataracts," Nature, Nature, vol. 523(7562), pages 607-611, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7562:d:10.1038_nature14650
    DOI: 10.1038/nature14650
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    Cited by:

    1. Lianyu Zhou & Huichun Xie & Xuelan Ma & Jiasheng Ju & Qiaoyu Luo & Feng Qiao, 2022. "Effect of Sodium Selenite Concentration and Culture Time on Extracellular and Intracellular Metabolite Profiles of Epichloë sp. Isolated from Festuca sinensis in Liquid Culture," Agriculture, MDPI, vol. 12(9), pages 1-23, September.

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