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Parent stem cells can serve as niches for their daughter cells

Author

Listed:
  • Ana Pardo-Saganta

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Pulmonary and Critical Care Unit, Massachusetts General Hospital
    Harvard Stem Cell Institute)

  • Purushothama Rao Tata

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Pulmonary and Critical Care Unit, Massachusetts General Hospital
    Harvard Stem Cell Institute)

  • Brandon M. Law

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Pulmonary and Critical Care Unit, Massachusetts General Hospital
    Harvard Stem Cell Institute)

  • Borja Saez

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Stem Cell Institute
    Harvard University)

  • Ryan Dz-Wei Chow

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Pulmonary and Critical Care Unit, Massachusetts General Hospital
    Harvard Stem Cell Institute)

  • Mythili Prabhu

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Pulmonary and Critical Care Unit, Massachusetts General Hospital
    Harvard Stem Cell Institute)

  • Thomas Gridley

    (Center for Molecular Medicine, Maine Medical Center Research Institute)

  • Jayaraj Rajagopal

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Pulmonary and Critical Care Unit, Massachusetts General Hospital
    Harvard Stem Cell Institute)

Abstract

Little is known about how the relative proportions of stem cells and differentiated cells are regulated; basal stem/progenitor cells of the mouse airway epithelium self renew and differentiate into secretory and ciliated cells, and basal stem cells continuously send daughter cells a forward niche signal necessary for daughter cell fate maintenance.

Suggested Citation

  • Ana Pardo-Saganta & Purushothama Rao Tata & Brandon M. Law & Borja Saez & Ryan Dz-Wei Chow & Mythili Prabhu & Thomas Gridley & Jayaraj Rajagopal, 2015. "Parent stem cells can serve as niches for their daughter cells," Nature, Nature, vol. 523(7562), pages 597-601, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7562:d:10.1038_nature14553
    DOI: 10.1038/nature14553
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