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Parent–progeny sequencing indicates higher mutation rates in heterozygotes

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Listed:
  • Sihai Yang

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Long Wang

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Ju Huang

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Xiaohui Zhang

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Yang Yuan

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Jian-Qun Chen

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Laurence D. Hurst

    (The Milner Centre for Evolution, University of Bath)

  • Dacheng Tian

    (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

Abstract

Mutation rates vary within genomes; here, by calling mutation events directly using a parent–offspring sequencing strategy in Arabidopsis, replicated in the rice and honey bee genomes, mutation rates are found to be higher in heterozygotes and in proximity to crossover events.

Suggested Citation

  • Sihai Yang & Long Wang & Ju Huang & Xiaohui Zhang & Yang Yuan & Jian-Qun Chen & Laurence D. Hurst & Dacheng Tian, 2015. "Parent–progeny sequencing indicates higher mutation rates in heterozygotes," Nature, Nature, vol. 523(7561), pages 463-467, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7561:d:10.1038_nature14649
    DOI: 10.1038/nature14649
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    Cited by:

    1. Carla Bautista & Isabelle Gagnon-Arsenault & Mariia Utrobina & Anna Fijarczyk & Devin P. Bendixsen & Rike Stelkens & Christian R. Landry, 2024. "Hybrid adaptation is hampered by Haldane’s sieve," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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