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Single-cell chromatin accessibility reveals principles of regulatory variation

Author

Listed:
  • Jason D. Buenrostro

    (Stanford University School of Medicine
    Program in Epithelial Biology and the Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Beijing Wu

    (Stanford University School of Medicine)

  • Ulrike M. Litzenburger

    (Program in Epithelial Biology and the Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Dave Ruff

    (Fluidigm Corporation)

  • Michael L. Gonzales

    (Fluidigm Corporation)

  • Michael P. Snyder

    (Stanford University School of Medicine)

  • Howard Y. Chang

    (Program in Epithelial Biology and the Howard Hughes Medical Institute, Stanford University School of Medicine)

  • William J. Greenleaf

    (Stanford University School of Medicine
    Stanford University)

Abstract

A single-cell method for probing genome-wide chromatin accessibility has been developed; the results provide insight into the relationship between cell-to-cell variation associated with specific trans-factors and cis-elements, as well insights into the relationship between chromatin accessibility and three-dimensional genome organization.

Suggested Citation

  • Jason D. Buenrostro & Beijing Wu & Ulrike M. Litzenburger & Dave Ruff & Michael L. Gonzales & Michael P. Snyder & Howard Y. Chang & William J. Greenleaf, 2015. "Single-cell chromatin accessibility reveals principles of regulatory variation," Nature, Nature, vol. 523(7561), pages 486-490, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7561:d:10.1038_nature14590
    DOI: 10.1038/nature14590
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