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Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment

Author

Listed:
  • Pulin Li

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
    Chemical Biology Program, Harvard University)

  • Jamie L. Lahvic

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Vera Binder

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
    Dr. von Hauner Children's Hospital, Ludwig-Maximilians University)

  • Emily K. Pugach

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Elizabeth B. Riley

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Owen J. Tamplin

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Dipak Panigrahy

    (Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Teresa V. Bowman

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Francesca G. Barrett

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Garrett C. Heffner

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Shannon McKinney-Freeman

    (St Jude Children's Research Hospital)

  • Thorsten M. Schlaeger

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • George Q. Daley

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School)

  • Darryl C. Zeldin

    (National Institute of Environmental Health Sciences, National Institutes of Health)

  • Leonard I. Zon

    (Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School
    Chemical Biology Program, Harvard University)

Abstract

An in vivo imaging-based competitive transplant screen in zebrafish identifies epoxyeicosatrienoic acids as enhancers of haematopoietic stem and progenitor cell (HSPC) engraftment; these derivatives of arachidonic acid also promote zebrafish developmental HSPC specification through a PI(3)K-dependent AP-1 and runx1 transcriptional program and their pro-engraftment effect is conserved in mammals (indicating clinical potential).

Suggested Citation

  • Pulin Li & Jamie L. Lahvic & Vera Binder & Emily K. Pugach & Elizabeth B. Riley & Owen J. Tamplin & Dipak Panigrahy & Teresa V. Bowman & Francesca G. Barrett & Garrett C. Heffner & Shannon McKinney-Fr, 2015. "Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment," Nature, Nature, vol. 523(7561), pages 468-471, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7561:d:10.1038_nature14569
    DOI: 10.1038/nature14569
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