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A noisy linear map underlies oscillations in cell size and gene expression in bacteria

Author

Listed:
  • Yu Tanouchi

    (Duke University)

  • Anand Pai

    (Duke University)

  • Heungwon Park

    (Duke University
    Duke University)

  • Shuqiang Huang

    (Duke University)

  • Rumen Stamatov

    (Computational Biology and Bioinformatics, Duke University)

  • Nicolas E. Buchler

    (Duke University
    Duke University
    Center for Genomic and Computational Biology, Duke University)

  • Lingchong You

    (Duke University
    Center for Genomic and Computational Biology, Duke University)

Abstract

Quantification of single-cell growth over long periods of time in E. coli shows transient oscillations in cell size, with periods stretching across more than ten generations; a noisy negative feedback on cell-size control is proposed in which cells with a small initial size tend to divide later than cells with a large initial size with implications for the genetic and physiological processes required.

Suggested Citation

  • Yu Tanouchi & Anand Pai & Heungwon Park & Shuqiang Huang & Rumen Stamatov & Nicolas E. Buchler & Lingchong You, 2015. "A noisy linear map underlies oscillations in cell size and gene expression in bacteria," Nature, Nature, vol. 523(7560), pages 357-360, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7560:d:10.1038_nature14562
    DOI: 10.1038/nature14562
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    Cited by:

    1. Nieto, César & Vargas, Cesar & Singh, Abhyudai, 2023. "Statistical properties of dynamical models underlying cell size homeostasis," OSF Preprints ea6yx, Center for Open Science.
    2. Diederik S. Laman Trip & Théo Maire & Hyun Youk, 2022. "Slowest possible replicative life at frigid temperatures for yeast," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Harsh Vashistha & Joanna Jammal-Touma & Kulveer Singh & Yitzhak Rabin & Hanna Salman, 2023. "Bacterial cell-size changes resulting from altering the relative expression of Min proteins," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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