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Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer

Author

Listed:
  • Zhenfei Li

    (Lerner Research Institute, Cleveland Clinic)

  • Andrew C. Bishop

    (Lerner Research Institute, Cleveland Clinic)

  • Mohammad Alyamani

    (Lerner Research Institute, Cleveland Clinic)

  • Jorge A. Garcia

    (Taussig Cancer Institute, Cleveland Clinic
    Glickman Urological and Kidney Institute, Cleveland Clinic)

  • Robert Dreicer

    (Taussig Cancer Institute, Cleveland Clinic
    Glickman Urological and Kidney Institute, Cleveland Clinic)

  • Dustin Bunch

    (Pathology and Laboratory Medicine Institute, Cleveland Clinic)

  • Jiayan Liu

    (University of Michigan Medical School)

  • Sunil K. Upadhyay

    (University of Michigan Medical School)

  • Richard J. Auchus

    (University of Michigan Medical School
    University of Michigan Medical School)

  • Nima Sharifi

    (Lerner Research Institute, Cleveland Clinic
    Taussig Cancer Institute, Cleveland Clinic
    Glickman Urological and Kidney Institute, Cleveland Clinic)

Abstract

The drug abiraterone is converted to Δ4-abiraterone (D4A) in mice and patients with prostate cancer, which has more potent anti-tumour activity and may lead to more effective therapies.

Suggested Citation

  • Zhenfei Li & Andrew C. Bishop & Mohammad Alyamani & Jorge A. Garcia & Robert Dreicer & Dustin Bunch & Jiayan Liu & Sunil K. Upadhyay & Richard J. Auchus & Nima Sharifi, 2015. "Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer," Nature, Nature, vol. 523(7560), pages 347-351, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7560:d:10.1038_nature14406
    DOI: 10.1038/nature14406
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