IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v523y2015i7559d10.1038_nature14473.html
   My bibliography  Save this article

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication

Author

Listed:
  • C. Lori

    (Focal area of Infection Biology, Biozentrum, University of Basel)

  • S. Ozaki

    (Focal area of Infection Biology, Biozentrum, University of Basel)

  • S. Steiner

    (Focal area of Infection Biology, Biozentrum, University of Basel
    †Present addresses: Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA (S.S.); UiT, The Arctic University of Norway, Department of Pharmacy, Faculty of Health Sciences, N-9037 Tromsø, Norway (S.A.).)

  • R. Böhm

    (Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel)

  • S. Abel

    (Focal area of Infection Biology, Biozentrum, University of Basel
    †Present addresses: Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA (S.S.); UiT, The Arctic University of Norway, Department of Pharmacy, Faculty of Health Sciences, N-9037 Tromsø, Norway (S.A.).)

  • B. N. Dubey

    (Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel)

  • T. Schirmer

    (Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel)

  • S. Hiller

    (Focal area of Structural Biology and Biophysics, Biozentrum, University of Basel)

  • U. Jenal

    (Focal area of Infection Biology, Biozentrum, University of Basel)

Abstract

In Caulobacter crescentus, oscillating levels of the second messenger cyclic-di-GMP drive the cell cycle through regulation of the essential cell cycle kinase CckA; as its levels increase during the G1–S transition, cyclic-di-GMP binds to CckA to inhibit kinase and stimulate phosphatase activity, thereby enabling replication initiation.

Suggested Citation

  • C. Lori & S. Ozaki & S. Steiner & R. Böhm & S. Abel & B. N. Dubey & T. Schirmer & S. Hiller & U. Jenal, 2015. "Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication," Nature, Nature, vol. 523(7559), pages 236-239, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7559:d:10.1038_nature14473
    DOI: 10.1038/nature14473
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14473
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14473?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mitchell Brüderlin & Raphael Böhm & Firas Fadel & Sebastian Hiller & Tilman Schirmer & Badri N. Dubey, 2023. "Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Andreas Kaczmarczyk & Simon Vliet & Roman Peter Jakob & Raphael Dias Teixeira & Inga Scheidat & Alberto Reinders & Alexander Klotz & Timm Maier & Urs Jenal, 2024. "A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Shuyu Li & Hengxi Sun & Jianghan Li & Yujiao Zhao & Ruiying Wang & Lei Xu & Chongyi Duan & Jialin Li & Zhuo Wang & Qinmeng Liu & Yao Wang & Songying Ouyang & Xihui Shen & Lei Zhang, 2022. "Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:523:y:2015:i:7559:d:10.1038_nature14473. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.