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Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour

Author

Listed:
  • Mathieu Frechin

    (Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich)

  • Thomas Stoeger

    (Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich
    Life Science Zurich Graduate School, Ph.D. program in Systems Biology. ETH Zurich and University of Zurich)

  • Stephan Daetwyler

    (Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich)

  • Charlotte Gehin

    (University of Geneva)

  • Nico Battich

    (Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich
    Life Science Zurich Graduate School, Ph.D. program in Systems Biology. ETH Zurich and University of Zurich)

  • Eva-Maria Damm

    (Institute of Molecular Systems Biology, ETH Zurich)

  • Lilli Stergiou

    (Institute of Molecular Systems Biology, ETH Zurich)

  • Howard Riezman

    (University of Geneva)

  • Lucas Pelkmans

    (Faculty of Sciences, Institute of Molecular Life Sciences, University of Zurich)

Abstract

Little is known about how individual cells within a group of cells exposed to the same external signals can produce a specific individual response to their local microenvironment; a quantitative analysis of cell crowding reveals that single cells can autonomously sense local crowding though their ability to spread and activate focal adhesion kinase (FAK), which ultimately results in changes in cellular lipid composition.

Suggested Citation

  • Mathieu Frechin & Thomas Stoeger & Stephan Daetwyler & Charlotte Gehin & Nico Battich & Eva-Maria Damm & Lilli Stergiou & Howard Riezman & Lucas Pelkmans, 2015. "Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour," Nature, Nature, vol. 523(7558), pages 88-91, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7558:d:10.1038_nature14429
    DOI: 10.1038/nature14429
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    Cited by:

    1. Nell Saunders & Blandine Monel & Nadège Cayet & Lorenzo Archetti & Hugo Moreno & Alexandre Jeanne & Agathe Marguier & Julian Buchrieser & Timothy Wai & Olivier Schwartz & Mathieu Fréchin, 2024. "Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Yuting Feng & Shuyi Wang & Xiaoye Liu & Yiming Han & Hongwei Xu & Xiaocen Duan & Wenyue Xie & Zhuoling Tian & Zuoying Yuan & Zhuo Wan & Liang Xu & Siying Qin & Kangmin He & Jianyong Huang, 2023. "Geometric constraint-triggered collagen expression mediates bacterial-host adhesion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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