IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v523y2015i7558d10.1038_nature14329.html
   My bibliography  Save this article

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

Author

Listed:
  • María Elena Fernández-Sánchez

    (Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes)

  • Sandrine Barbier

    (Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes)

  • Joanne Whitehead

    (Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes)

  • Gaëlle Béalle

    (UPMC, Sorbonne Universités, Laboratoire PHENIX Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, CNRS UMR 8234)

  • Aude Michel

    (UPMC, Sorbonne Universités, Laboratoire PHENIX Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, CNRS UMR 8234)

  • Heldmuth Latorre-Ossa

    (Langevin Institut, Waves and Images ESPCI ParisTech, PSL Research University, CNRS UMR7587, Inserm U979)

  • Colette Rey

    (Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine)

  • Laura Fouassier

    (Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine)

  • Audrey Claperon

    (Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine)

  • Laura Brullé

    (CNRS UMR3666/INSERM U1143, Endocytic Trafficking and Therapeutic Delivery, Institut Curie, Centre de Recherche)

  • Elodie Girard

    (Bioinformatic platform, U900, Institut Curie, MINES ParisTech)

  • Nicolas Servant

    (Bioinformatic platform, U900, Institut Curie, MINES ParisTech)

  • Thomas Rio-Frio

    (Next-generation sequencing platform, Institut Curie)

  • Hélène Marie

    (CNRS UMR 8612, Laboratoire Physico-Chimie des Systèmes Polyphasés, Institut Galien Paris-Sud, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud)

  • Sylviane Lesieur

    (CNRS UMR 8612, Laboratoire Physico-Chimie des Systèmes Polyphasés, Institut Galien Paris-Sud, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud)

  • Chantal Housset

    (Sorbonne Universités, UPMC and INSERM, UMR-S 938, CDR Saint-Antoine)

  • Jean-Luc Gennisson

    (Langevin Institut, Waves and Images ESPCI ParisTech, PSL Research University, CNRS UMR7587, Inserm U979)

  • Mickaël Tanter

    (Langevin Institut, Waves and Images ESPCI ParisTech, PSL Research University, CNRS UMR7587, Inserm U979)

  • Christine Ménager

    (UPMC, Sorbonne Universités, Laboratoire PHENIX Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux, CNRS UMR 8234)

  • Silvia Fre

    (CNRS UMR 3215/INSERM U934, Unité de Génétique et Biologie du Développement, Notch Signaling in Stem Cells and Tumors, Institut Curie, Centre de Recherche)

  • Sylvie Robine

    (CNRS UMR144, Compartimentation et dynamique cellulaires, Morphogenesis and Cell Signalling Institut Curie, Centre de Recherche)

  • Emmanuel Farge

    (Institut Curie, Centre de Recherche, PSL Research University, CNRS UMR 168, Physicochimie Curie Mechanics and Genetics of Embryonic and Tumour Development, INSERM, Fondation Pierre-Gilles de Gennes)

Abstract

Magnetically induced mechanical strain mimicking the pressure exerted by a growing tumour in the mouse colon is shown to activate the tumorigenic β-catenin pathway in healthy epithelia, suggesting an alternative pathway, mechanotransductive in nature, in the propagation of tumorigenesis and growth from tumour to healthy tissue.

Suggested Citation

  • María Elena Fernández-Sánchez & Sandrine Barbier & Joanne Whitehead & Gaëlle Béalle & Aude Michel & Heldmuth Latorre-Ossa & Colette Rey & Laura Fouassier & Audrey Claperon & Laura Brullé & Elodie Gira, 2015. "Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure," Nature, Nature, vol. 523(7558), pages 92-95, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7558:d:10.1038_nature14329
    DOI: 10.1038/nature14329
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14329
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14329?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:523:y:2015:i:7558:d:10.1038_nature14329. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.