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UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

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Listed:
  • Mark D. White

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Karl A. P. Payne

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Karl Fisher

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Stephen A. Marshall

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • David Parker

    (Innovation/Biodomain, Shell International Exploration and Production, Westhollow Technology Center)

  • Nicholas J. W. Rattray

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Drupad K. Trivedi

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Royston Goodacre

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Stephen E. J. Rigby

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Nigel S. Scrutton

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • Sam Hay

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

  • David Leys

    (Centre for Synthetic Biology of Fine and Speciality Chemicals, Manchester Institute of Biotechnology, The University of Manchester)

Abstract

Ubiquinone is an essential component of electron transfer chains found both in bacteria and in mitochondria; the bacterial enzyme UbiX involved in ubiquinone biosynthesis is a flavin prenyltransferase, and the flavin-derived cofactor synthesized by UbiX is used by the UbiD decarboxylase in the ubiquinone biosynthetic pathway.

Suggested Citation

  • Mark D. White & Karl A. P. Payne & Karl Fisher & Stephen A. Marshall & David Parker & Nicholas J. W. Rattray & Drupad K. Trivedi & Royston Goodacre & Stephen E. J. Rigby & Nigel S. Scrutton & Sam Hay , 2015. "UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis," Nature, Nature, vol. 522(7557), pages 502-506, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14559
    DOI: 10.1038/nature14559
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