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Cell death during crisis is mediated by mitotic telomere deprotection

Author

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  • Makoto T. Hayashi

    (The Salk Institute for Biological Studies
    Graduate School of Biostudies/The Hakubi Center for Advanced Research, Kyoto University)

  • Anthony J. Cesare

    (The Salk Institute for Biological Studies
    Children's Medical Research Institute, University of Sydney)

  • Teresa Rivera

    (The Salk Institute for Biological Studies)

  • Jan Karlseder

    (The Salk Institute for Biological Studies)

Abstract

Cells that bypass senescence in the absence of the p53 tumour suppressor protein have shortened telomeres that undergo fusion, and these fusions trigger mitotic arrest and cell death in crisis.

Suggested Citation

  • Makoto T. Hayashi & Anthony J. Cesare & Teresa Rivera & Jan Karlseder, 2015. "Cell death during crisis is mediated by mitotic telomere deprotection," Nature, Nature, vol. 522(7557), pages 492-496, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14513
    DOI: 10.1038/nature14513
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