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The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

Author

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  • Ditte S. Andersen

    (University of Nice-Sophia Antipolis, Institute of Biology Valrose
    CNRS, Institute of Biology Valrose
    INSERM, Institute of Biology Valrose
    Genetics and Physiology of Growth laboratory, Institute of Biology Valrose)

  • Julien Colombani

    (University of Nice-Sophia Antipolis, Institute of Biology Valrose
    CNRS, Institute of Biology Valrose
    INSERM, Institute of Biology Valrose
    Genetics and Physiology of Growth laboratory, Institute of Biology Valrose)

  • Valentina Palmerini

    (European Institute of Oncology)

  • Krittalak Chakrabandhu

    (University of Nice-Sophia Antipolis, Institute of Biology Valrose
    CNRS, Institute of Biology Valrose
    INSERM, Institute of Biology Valrose
    Death receptors Signalling and Cancer Therapy laboratory, Institute of Biology Valrose)

  • Emilie Boone

    (University of Nice-Sophia Antipolis, Institute of Biology Valrose
    CNRS, Institute of Biology Valrose
    INSERM, Institute of Biology Valrose
    Genetics and Physiology of Growth laboratory, Institute of Biology Valrose)

  • Michael Röthlisberger

    (Institute of Molecular Life Sciences, University of Zurich)

  • Janine Toggweiler

    (Institute of Molecular Life Sciences, University of Zurich)

  • Konrad Basler

    (Institute of Molecular Life Sciences, University of Zurich)

  • Marina Mapelli

    (European Institute of Oncology)

  • Anne-Odile Hueber

    (University of Nice-Sophia Antipolis, Institute of Biology Valrose
    CNRS, Institute of Biology Valrose
    INSERM, Institute of Biology Valrose
    Death receptors Signalling and Cancer Therapy laboratory, Institute of Biology Valrose)

  • Pierre Léopold

    (University of Nice-Sophia Antipolis, Institute of Biology Valrose
    CNRS, Institute of Biology Valrose
    INSERM, Institute of Biology Valrose
    Genetics and Physiology of Growth laboratory, Institute of Biology Valrose)

Abstract

Cell polarity is an important feature of many tissues and is often disrupted in cancer; the TNF receptor Grindelwald is now shown to have an important role in coordinating cell polarity and neoplastic growth in a Drosophila model.

Suggested Citation

  • Ditte S. Andersen & Julien Colombani & Valentina Palmerini & Krittalak Chakrabandhu & Emilie Boone & Michael Röthlisberger & Janine Toggweiler & Konrad Basler & Marina Mapelli & Anne-Odile Hueber & Pi, 2015. "The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth," Nature, Nature, vol. 522(7557), pages 482-486, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14298
    DOI: 10.1038/nature14298
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    Cited by:

    1. Peng Zhang & Stephen M. Pronovost & Marco Marchetti & Chenge Zhang & Xiaoyu Kang & Tahmineh Kandelouei & Christopher Li & Bruce A. Edgar, 2024. "Inter-cell type interactions that control JNK signaling in the Drosophila intestine," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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