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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Author

Listed:
  • W. Peelaerts

    (KU Leuven, Laboratory for Neurobiology and Gene Therapy)

  • L. Bousset

    (Paris-Saclay Institute of Neuroscience, CNRS)

  • A. Van der Perren

    (KU Leuven, Laboratory for Neurobiology and Gene Therapy)

  • A. Moskalyuk

    (Theoretical Neurobiology & Neuroengineering Laboratory, University of Antwerp)

  • R. Pulizzi

    (Theoretical Neurobiology & Neuroengineering Laboratory, University of Antwerp)

  • M. Giugliano

    (Theoretical Neurobiology & Neuroengineering Laboratory, University of Antwerp
    University of Sheffield
    Brain Mind Institute, Swiss Federal Institute of Technology of Lausanne
    Neuro-Electronics Research Flanders (NERF))

  • C. Van den Haute

    (KU Leuven, Laboratory for Neurobiology and Gene Therapy
    KU Leuven, Leuven Viral Vector Core)

  • R. Melki

    (Paris-Saclay Institute of Neuroscience, CNRS)

  • V. Baekelandt

    (KU Leuven, Laboratory for Neurobiology and Gene Therapy)

Abstract

Brain α-synuclein deposits are the hallmark of various distinct neurodegenerative diseases, and it is proposed that α-synuclein assemblies with different structural characteristics or 'strains' (ribbons or fibrils) could account for pathological differences between these diseases; here different human α-synuclein strains are injected into rat brain, and are shown to propagate in a strain-dependent manner and cause different pathological and neurotoxic phenotypes.

Suggested Citation

  • W. Peelaerts & L. Bousset & A. Van der Perren & A. Moskalyuk & R. Pulizzi & M. Giugliano & C. Van den Haute & R. Melki & V. Baekelandt, 2015. "α-Synuclein strains cause distinct synucleinopathies after local and systemic administration," Nature, Nature, vol. 522(7556), pages 340-344, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14547
    DOI: 10.1038/nature14547
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    Cited by:

    1. Iosif Pediaditakis & Konstantia R. Kodella & Dimitris V. Manatakis & Christopher Y. Le & Chris D. Hinojosa & William Tien-Street & Elias S. Manolakos & Kostas Vekrellis & Geraldine A. Hamilton & Lorna, 2021. "Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Sabine M. Ulamec & Roberto Maya-Martinez & Emily J. Byrd & Katherine M. Dewison & Yong Xu & Leon F. Willis & Frank Sobott & George R. Heath & Patricija Oosten Hawle & Vladimir L. Buchman & Sheena E. R, 2022. "Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Norihito Uemura & Nicholas P. Marotta & Jahan Ara & Emily S. Meymand & Bin Zhang & Hiroshi Kameda & Masato Koike & Kelvin C. Luk & John Q. Trojanowski & Virginia M.-Y. Lee, 2023. "α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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