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MET is required for the recruitment of anti-tumoural neutrophils

Author

Listed:
  • Veronica Finisguerra

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center)

  • Giusy Di Conza

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center)

  • Mario Di Matteo

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center)

  • Jens Serneels

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center)

  • Sandra Costa

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho
    ICVS/3B's - PT Government Associate Laboratory)

  • A. A. Roger Thompson

    (University of Sheffield)

  • Els Wauters

    (University Hospital Gasthuisberg
    Laboratory of Translational Genetics, Vesalius Research Center, VIB
    Laboratory of Translational Genetics, Vesalius Research Center, KU Leuven)

  • Sarah Walmsley

    (University of Sheffield
    † Present address: MRC/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.)

  • Hans Prenen

    (Digestive Oncology Unit, University Hospital Gasthuisberg, KU Leuven)

  • Zvi Granot

    (The Institute for Medical Research Israel-Canada, The Hebrew University)

  • Andrea Casazza

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center)

  • Massimiliano Mazzone

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center)

Abstract

Whether neutrophils exert an anti- or pro-tumorigenic function has remained controversial; now, expression of the receptor molecule MET in neutrophils is shown to be required for their ability to restrict tumour growth in several mouse cancer models, with potential implications for human cancer therapy.

Suggested Citation

  • Veronica Finisguerra & Giusy Di Conza & Mario Di Matteo & Jens Serneels & Sandra Costa & A. A. Roger Thompson & Els Wauters & Sarah Walmsley & Hans Prenen & Zvi Granot & Andrea Casazza & Massimiliano , 2015. "MET is required for the recruitment of anti-tumoural neutrophils," Nature, Nature, vol. 522(7556), pages 349-353, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14407
    DOI: 10.1038/nature14407
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    Cited by:

    1. Ting Wang & Yingli Zhou & Zilong Zhou & Pinggen Zhang & Ronghui Yan & Linchong Sun & Wenhao Ma & Tong Zhang & Shengqi Shen & Haiying Liu & Hui Lu & Ling Ye & Junru Feng & Zhaolin Chen & Xiuying Zhong , 2023. "Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Charlotte R. Bell & Victoria S. Pelly & Agrin Moeini & Shih-Chieh Chiang & Eimear Flanagan & Christian P. Bromley & Christopher Clark & Charles H. Earnshaw & Maria A. Koufaki & Eduardo Bonavita & Sant, 2022. "Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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