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Synthesis and applications of RNAs with position-selective labelling and mosaic composition

Author

Listed:
  • Yu Liu

    (Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Erik Holmstrom

    (JILA, University of Colorado)

  • Jinwei Zhang

    (Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute)

  • Ping Yu

    (Structural Biophysics Laboratory, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research)

  • Jinbu Wang

    (Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Marzena A. Dyba

    (Structural Biophysics Laboratory, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research)

  • De Chen

    (Optical Microscopy and Analysis Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research)

  • Jinfa Ying

    (Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

  • Stephen Lockett

    (Optical Microscopy and Analysis Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research)

  • David J. Nesbitt

    (JILA, University of Colorado)

  • Adrian R. Ferré-D’Amaré

    (Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute)

  • Rui Sousa

    (University of Texas Health Science Center)

  • Jason R. Stagno

    (Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Yun-Xing Wang

    (Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

Abstract

A hybrid solid–liquid phase transcription method and automated robotic platform synthesizes position-specific, fluorescence- or isotope-labelled RNA.

Suggested Citation

  • Yu Liu & Erik Holmstrom & Jinwei Zhang & Ping Yu & Jinbu Wang & Marzena A. Dyba & De Chen & Jinfa Ying & Stephen Lockett & David J. Nesbitt & Adrian R. Ferré-D’Amaré & Rui Sousa & Jason R. Stagno & Yu, 2015. "Synthesis and applications of RNAs with position-selective labelling and mosaic composition," Nature, Nature, vol. 522(7556), pages 368-372, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7556:d:10.1038_nature14352
    DOI: 10.1038/nature14352
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    Citations

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    Cited by:

    1. Xiaolin Niu & Zhonghe Xu & Yufan Zhang & Xiaobing Zuo & Chunlai Chen & Xianyang Fang, 2023. "Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yanyan Xue & Jun Li & Dian Chen & Xizhu Zhao & Liang Hong & Yu Liu, 2023. "Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Mária Brunderová & Vojtěch Havlíček & Ján Matyašovský & Radek Pohl & Lenka Poštová Slavětínská & Matouš Krömer & Michal Hocek, 2024. "Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Raphael Haslecker & Vincent V. Pham & David Glänzer & Christoph Kreutz & Theodore Kwaku Dayie & Victoria M. D’Souza, 2023. "Extending the toolbox for RNA biology with SegModTeX: a polymerase-driven method for site-specific and segmental labeling of RNA," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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