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Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

Author

Listed:
  • Edward J. Grow

    (Stanford University School of Medicine)

  • Ryan A. Flynn

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Shawn L. Chavez

    (Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University
    Stanford University School of Medicine, Stanford University
    Oregon National Primate Research Center, Oregon Health & Science University)

  • Nicholas L. Bayless

    (Stanford Immunology, Stanford University School of Medicine)

  • Mark Wossidlo

    (Stanford University School of Medicine
    Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University
    Stanford University School of Medicine, Stanford University)

  • Daniel J. Wesche

    (Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University)

  • Lance Martin

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Carol B. Ware

    (University of Washington)

  • Catherine A. Blish

    (Stanford University School of Medicine)

  • Howard Y. Chang

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Renee A. Reijo Pera

    (Stanford University School of Medicine
    Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University
    Stanford University School of Medicine, Stanford University
    Montana State University)

  • Joanna Wysocka

    (Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University
    Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed, producing retroviral-like particles.

Suggested Citation

  • Edward J. Grow & Ryan A. Flynn & Shawn L. Chavez & Nicholas L. Bayless & Mark Wossidlo & Daniel J. Wesche & Lance Martin & Carol B. Ware & Catherine A. Blish & Howard Y. Chang & Renee A. Reijo Pera & , 2015. "Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells," Nature, Nature, vol. 522(7555), pages 221-225, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7555:d:10.1038_nature14308
    DOI: 10.1038/nature14308
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    Cited by:

    1. Dasol Han & Guojing Liu & Yujeong Oh & Seyoun Oh & Seungbok Yang & Lori Mandjikian & Neha Rani & Maria C. Almeida & Kenneth S. Kosik & Jiwon Jang, 2023. "ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Marianne Yoth & Stéphanie Maupetit-Méhouas & Abdou Akkouche & Nathalie Gueguen & Benjamin Bertin & Silke Jensen & Emilie Brasset, 2023. "Reactivation of a somatic errantivirus and germline invasion in Drosophila ovaries," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Chunhong Yu & Xiaoyun Lei & Fang Chen & Song Mao & Lu Lv & Honglu Liu & Xueying Hu & Runhan Wang & Licong Shen & Na Zhang & Yang Meng & Yunfan Shen & Jiale Chen & Pishun Li & Shi Huang & Changwei Lin , 2022. "ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Poonam Dhillon & Kelly Ann Mulholland & Hailong Hu & Jihwan Park & Xin Sheng & Amin Abedini & Hongbo Liu & Allison Vassalotti & Junnan Wu & Katalin Susztak, 2023. "Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Zhengyi Li & Haiyan Xu & Jiaqun Li & Xiao Xu & Junjiao Wang & Danya Wu & Jiateng Zhang & Juan Liu & Ziwei Xue & Guankai Zhan & Bobby Cheng Peow Tan & Di Chen & Yun-Shen Chan & Huck Hui Ng & Wanlu Liu , 2023. "Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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