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Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

Author

Listed:
  • Harrison W. Gabel

    (Harvard Medical School)

  • Benyam Kinde

    (Harvard Medical School)

  • Hume Stroud

    (Harvard Medical School)

  • Caitlin S. Gilbert

    (Harvard Medical School)

  • David A. Harmin

    (Harvard Medical School)

  • Nathaniel R. Kastan

    (Harvard Medical School)

  • Martin Hemberg

    (Children’s Hospital Boston, Center for Brain Science and Swartz Center for Theoretical Neuroscience, Harvard University, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Present address: Computational Genomics Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.)

  • Daniel H. Ebert

    (Harvard Medical School)

  • Michael E. Greenberg

    (Harvard Medical School)

Abstract

Rett syndrome is caused by mutation of the MECP2 gene that codes for a protein that binds methylated DNA; this study reveals that MeCP2 affects the expression of long genes, which often serve neuronal functions.

Suggested Citation

  • Harrison W. Gabel & Benyam Kinde & Hume Stroud & Caitlin S. Gilbert & David A. Harmin & Nathaniel R. Kastan & Martin Hemberg & Daniel H. Ebert & Michael E. Greenberg, 2015. "Disruption of DNA-methylation-dependent long gene repression in Rett syndrome," Nature, Nature, vol. 522(7554), pages 89-93, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7554:d:10.1038_nature14319
    DOI: 10.1038/nature14319
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    Cited by:

    1. Yongjun Piao & Wanxue Xu & Kwang Ho Park & Keun Ho Ryu & Rong Xiang, 2021. "Comprehensive Evaluation of Differential Methylation Analysis Methods for Bisulfite Sequencing Data," IJERPH, MDPI, vol. 18(15), pages 1-15, July.
    2. Chen Sun & Kunal Kathuria & Sarah B. Emery & ByungJun Kim & Ian E. Burbulis & Joo Heon Shin & Daniel R. Weinberger & John V. Moran & Jeffrey M. Kidd & Ryan E. Mills & Michael J. McConnell, 2024. "Mapping recurrent mosaic copy number variation in human neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Xuan Zhang & Jun Xu & Jing Hu & Sitao Zhang & Yajing Hao & Dongyang Zhang & Hao Qian & Dong Wang & Xiang-Dong Fu, 2024. "Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Ravneet Jaura & Ssu-Yu Yeh & Kaitlin N. Montanera & Alyssa Ialongo & Zobia Anwar & Yiming Lu & Kavindu Puwakdandawa & Ho Sung Rhee, 2022. "Extended intergenic DNA contributes to neuron-specific expression of neighboring genes in the mammalian nervous system," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Raphaël Pantier & Megan Brown & Sicheng Han & Katie Paton & Stephen Meek & Thomas Montavon & Nicholas Shukeir & Toni McHugh & David A. Kelly & Tino Hochepied & Claude Libert & Thomas Jenuwein & Tom Bu, 2024. "MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Deivid C. Rodrigues & Marat Mufteev & Kyoko E. Yuki & Ashrut Narula & Wei Wei & Alina Piekna & Jiajie Liu & Peter Pasceri & Olivia S. Rissland & Michael D. Wilson & James Ellis, 2023. "Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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