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Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool

Author

Listed:
  • Kailin R. Mesa

    (Yale School of Medicine)

  • Panteleimon Rompolas

    (Yale School of Medicine)

  • Giovanni Zito

    (University of Palermo)

  • Peggy Myung

    (Yale School of Medicine
    Yale School of Medicine)

  • Thomas Y. Sun

    (Yale School of Medicine)

  • Samara Brown

    (Yale School of Medicine)

  • David G. Gonzalez

    (Yale School of Medicine)

  • Krastan B. Blagoev

    (National Science Foundation
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School)

  • Ann M. Haberman

    (Yale School of Medicine)

  • Valentina Greco

    (Yale School of Medicine
    Yale School of Medicine
    Yale Stem Cell Center, Yale School of Medicine
    Yale Cancer Center, Yale School of Medicine)

Abstract

Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.

Suggested Citation

  • Kailin R. Mesa & Panteleimon Rompolas & Giovanni Zito & Peggy Myung & Thomas Y. Sun & Samara Brown & David G. Gonzalez & Krastan B. Blagoev & Ann M. Haberman & Valentina Greco, 2015. "Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool," Nature, Nature, vol. 522(7554), pages 94-97, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7554:d:10.1038_nature14306
    DOI: 10.1038/nature14306
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    Cited by:

    1. Hadas Sibony-Benyamini & Emil Aamar & David Enshell-Seijffers, 2023. "Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Marianna Yusupova & Roi Ankawa & Yahav Yosefzon & David Meiri & Ido Bachelet & Yaron Fuchs, 2023. "Apoptotic dysregulation mediates stem cell competition and tissue regeneration," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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