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Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42

Author

Listed:
  • Seung-Yeol Park

    (Immunology and Allergy, Brigham and Women’s Hospital
    Harvard Medical School)

  • Jia-Shu Yang

    (Immunology and Allergy, Brigham and Women’s Hospital
    Harvard Medical School)

  • Angela B. Schmider

    (Harvard Medical School
    Massachusetts General Hospital)

  • Roy J. Soberman

    (Harvard Medical School
    Massachusetts General Hospital
    Molecular Imaging Core, Massachusetts General Hospital)

  • Victor W. Hsu

    (Immunology and Allergy, Brigham and Women’s Hospital
    Harvard Medical School)

Abstract

The COPI complex, which has a role in retrograde transport through the Golgi, is shown to also mediate anterograde tubular transport through the Golgi; in response to external stimuli, the small GTPase CDC42 acts as an essential modulator of bidirectional Golgi transport, and promotes the sorting of cargoes destined for anterograde transport into the tubules at the expense of those targeted for retrograde transport.

Suggested Citation

  • Seung-Yeol Park & Jia-Shu Yang & Angela B. Schmider & Roy J. Soberman & Victor W. Hsu, 2015. "Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42," Nature, Nature, vol. 521(7553), pages 529-532, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7553:d:10.1038_nature14457
    DOI: 10.1038/nature14457
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    Cited by:

    1. Alberto Iannuzzo & Selket Delafontaine & Rana El Masri & Rachida Tacine & Giusi Prencipe & Masahiko Nishitani-Isa & Rogier T. A. Wijck & Farzana Bhuyan & Adriana A. Jesus Rasheed & Simona Coppola & Pa, 2024. "Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation and ER stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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