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Atomic structure of anthrax protective antigen pore elucidates toxin translocation

Author

Listed:
  • Jiansen Jiang

    (Immunology and Molecular Genetics, University of California
    California NanoSystems Institute, University of California)

  • Bradley L. Pentelute

    (Massachusetts Institute of Technology)

  • R. John Collier

    (Harvard Medical School)

  • Z. Hong Zhou

    (Immunology and Molecular Genetics, University of California
    California NanoSystems Institute, University of California)

Abstract

Cryo-electron microscopy determination of anthrax toxin protective antigen pore structure at a resolution of 2.9 Å, revealing the catalytic Φ-clamp and the membrane-spanning translocation channel.

Suggested Citation

  • Jiansen Jiang & Bradley L. Pentelute & R. John Collier & Z. Hong Zhou, 2015. "Atomic structure of anthrax protective antigen pore elucidates toxin translocation," Nature, Nature, vol. 521(7553), pages 545-549, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7553:d:10.1038_nature14247
    DOI: 10.1038/nature14247
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    Cited by:

    1. B. U. Klink & A. Alavizargar & K. S. Kalyankumar & M. Chen & A. Heuer & C. Gatsogiannis, 2024. "Structural basis of α-latrotoxin transition to a cation-selective pore," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Johnny Lisboa & Cassilda Pereira & Rute D. Pinto & Inês S. Rodrigues & Liliana M. G. Pereira & Bruno Pinheiro & Pedro Oliveira & Pedro José Barbosa Pereira & Jorge E. Azevedo & Dominique Durand & Rola, 2023. "Unconventional structure and mechanisms for membrane interaction and translocation of the NF-κB-targeting toxin AIP56," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Akihiro Kawamoto & Tomohito Yamada & Toru Yoshida & Yusui Sato & Takayuki Kato & Hideaki Tsuge, 2022. "Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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