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Recursive splicing in long vertebrate genes

Author

Listed:
  • Christopher R. Sibley

    (UCL Institute of Neurology
    MRC Laboratory of Molecular Biology)

  • Warren Emmett

    (University College London Genetics Institute)

  • Lorea Blazquez

    (UCL Institute of Neurology)

  • Ana Faro

    (University College London)

  • Nejc Haberman

    (UCL Institute of Neurology)

  • Michael Briese

    (MRC Laboratory of Molecular Biology
    Institute for Clinical Neurobiology, University of Würzburg)

  • Daniah Trabzuni

    (UCL Institute of Neurology
    King Faisal Specialist Hospital and Research Centre)

  • Mina Ryten

    (UCL Institute of Neurology
    King’s College London, Guy’s Hospital)

  • Michael E. Weale

    (King’s College London, Guy’s Hospital)

  • John Hardy

    (UCL Institute of Neurology)

  • Miha Modic

    (MRC Laboratory of Molecular Biology
    Institute of Stem Cell Research, German Research Center for Environmental Health, Helmholtz Center Munich)

  • Tomaž Curk

    (Faculty of Computer and Information Science, University of Ljubljana)

  • Stephen W. Wilson

    (University College London)

  • Vincent Plagnol

    (University College London Genetics Institute)

  • Jernej Ule

    (UCL Institute of Neurology
    MRC Laboratory of Molecular Biology)

Abstract

Highly conserved recursive splice sites are identified in vertebrates, particularly within long genes encoding proteins that are involved in neuronal development; analysis of the splicing mechanism reveals that such recursive splicing sites can be used to dictate different mRNA isoforms.

Suggested Citation

  • Christopher R. Sibley & Warren Emmett & Lorea Blazquez & Ana Faro & Nejc Haberman & Michael Briese & Daniah Trabzuni & Mina Ryten & Michael E. Weale & John Hardy & Miha Modic & Tomaž Curk & Stephen W., 2015. "Recursive splicing in long vertebrate genes," Nature, Nature, vol. 521(7552), pages 371-375, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7552:d:10.1038_nature14466
    DOI: 10.1038/nature14466
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