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Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Author

Listed:
  • Emily P. Thi

    (Tekmira Pharmaceuticals)

  • Chad E. Mire

    (Galveston National Laboratory, University of Texas Medical Branch
    University of Texas Medical Branch)

  • Amy C. H. Lee

    (Tekmira Pharmaceuticals)

  • Joan B. Geisbert

    (Galveston National Laboratory, University of Texas Medical Branch
    University of Texas Medical Branch)

  • Joy Z. Zhou

    (Tekmira Pharmaceuticals)

  • Krystle N. Agans

    (Galveston National Laboratory, University of Texas Medical Branch
    University of Texas Medical Branch)

  • Nicholas M. Snead

    (Tekmira Pharmaceuticals)

  • Daniel J. Deer

    (Galveston National Laboratory, University of Texas Medical Branch
    University of Texas Medical Branch)

  • Trisha R. Barnard

    (Tekmira Pharmaceuticals)

  • Karla A. Fenton

    (Galveston National Laboratory, University of Texas Medical Branch
    University of Texas Medical Branch)

  • Ian MacLachlan

    (Tekmira Pharmaceuticals)

  • Thomas W. Geisbert

    (Galveston National Laboratory, University of Texas Medical Branch
    University of Texas Medical Branch)

Abstract

Ebola-virus-targeting short interfering RNAs (siRNAs) encapsulated in lipid nanoparticles are adapted to the current outbreak strain of the virus, and the siRNA cocktail is shown to protect nonhuman primates fully when administered 3 days after challenge with the current West African Ebola virus isolate; upon viral sequence data availability, the drug can be adapted to the new virus and produced in as little as 8 weeks.

Suggested Citation

  • Emily P. Thi & Chad E. Mire & Amy C. H. Lee & Joan B. Geisbert & Joy Z. Zhou & Krystle N. Agans & Nicholas M. Snead & Daniel J. Deer & Trisha R. Barnard & Karla A. Fenton & Ian MacLachlan & Thomas W. , 2015. "Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates," Nature, Nature, vol. 521(7552), pages 362-365, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7552:d:10.1038_nature14442
    DOI: 10.1038/nature14442
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