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Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

Author

Listed:
  • Zhengshan Chen

    (University of California)

  • Seyedmehdi Shojaee

    (University of California)

  • Maike Buchner

    (University of California)

  • Huimin Geng

    (University of California)

  • Jae Woong Lee

    (University of California)

  • Lars Klemm

    (University of California)

  • Björn Titz

    (Crump Institute for Molecular Imaging, University of California)

  • Thomas G. Graeber

    (Crump Institute for Molecular Imaging, University of California)

  • Eugene Park

    (University of California)

  • Ying Xim Tan

    (Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California)

  • Anne Satterthwaite

    (University of Texas Southwestern Medical Center)

  • Elisabeth Paietta

    (Albert Einstein College of Medicine)

  • Stephen P. Hunger

    (Children’s Hospital of Philadelphia)

  • Cheryl L. Willman

    (University of New Mexico Cancer Center)

  • Ari Melnick

    (Weill Cornell Medical College)

  • Mignon L. Loh

    (Pediatric Hematology-Oncology, University of California)

  • Jae U. Jung

    (University of Southern California)

  • John E. Coligan

    (Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Silvia Bolland

    (Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Tak W. Mak

    (The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, Ontario M5G 2M9, Canada)

  • Andre Limnander

    (University of California)

  • Hassan Jumaa

    (Institute of Immunology, University Clinics Ulm, 89081 Ulm, Germany)

  • Michael Reth

    (BIOSS Centre for Biological Signalling Studies and Faculty of Biology, Albert-Ludwigs-Universität Freiburg, and MPI of Immunbiologie and Epigenetics, 79104 Freiburg, Germany)

  • Arthur Weiss

    (Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California)

  • Clifford A. Lowell

    (University of California)

  • Markus Müschen

    (University of California)

Abstract

This study shows that, despite malignant transformation, autoimmune checkpoints are still functional in B-cell leukaemia, with targeted activation of these checkpoints effectively killing patient-derived B-cell leukaemia in a transplant model; the results represent a novel strategy to overcome drug resistance in leukaemia patients.

Suggested Citation

  • Zhengshan Chen & Seyedmehdi Shojaee & Maike Buchner & Huimin Geng & Jae Woong Lee & Lars Klemm & Björn Titz & Thomas G. Graeber & Eugene Park & Ying Xim Tan & Anne Satterthwaite & Elisabeth Paietta & , 2015. "Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia," Nature, Nature, vol. 521(7552), pages 357-361, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7552:d:10.1038_nature14231
    DOI: 10.1038/nature14231
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    Citations

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    Cited by:

    1. Vicky Chou & Richard V. Pearse & Aimee J. Aylward & Nancy Ashour & Mariko Taga & Gizem Terzioglu & Masashi Fujita & Seeley B. Fancher & Alina Sigalov & Courtney R. Benoit & Hyo Lee & Matti Lam & Nicho, 2023. "INPP5D regulates inflammasome activation in human microglia," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    2. Isabelle Rose Leo & Luay Aswad & Matthias Stahl & Elena Kunold & Frederik Post & Tom Erkers & Nona Struyf & Georgios Mermelekas & Rubin Narayan Joshi & Eva Gracia-Villacampa & Päivi Östling & Olli P. , 2022. "Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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