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Nuclear architecture dictates HIV-1 integration site selection

Author

Listed:
  • Bruna Marini

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy)

  • Attila Kertesz-Farkas

    (Protein Structure and Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy)

  • Hashim Ali

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy)

  • Bojana Lucic

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
    Present addresses: Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany (B.L.; M.L.); Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie (LNCIB), 34149 Trieste, Italy (K.L.); Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (L.M.); Pazmany University, Budapest 1083, Hungary (S.P.).)

  • Kamil Lisek

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
    Present addresses: Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany (B.L.; M.L.); Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie (LNCIB), 34149 Trieste, Italy (K.L.); Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (L.M.); Pazmany University, Budapest 1083, Hungary (S.P.).)

  • Lara Manganaro

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
    Present addresses: Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany (B.L.; M.L.); Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie (LNCIB), 34149 Trieste, Italy (K.L.); Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (L.M.); Pazmany University, Budapest 1083, Hungary (S.P.).)

  • Sandor Pongor

    (Protein Structure and Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
    Present addresses: Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany (B.L.; M.L.); Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie (LNCIB), 34149 Trieste, Italy (K.L.); Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (L.M.); Pazmany University, Budapest 1083, Hungary (S.P.).)

  • Roberto Luzzati

    (Struttura Complessa Malattie Infettive, Azienda Ospedaliero-Universitaria, 34134 Trieste, Italy
    Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy)

  • Alessandra Recchia

    (University of Modena and Reggio Emilia, 41121 Modena, Italy)

  • Fulvio Mavilio

    (University of Modena and Reggio Emilia, 41121 Modena, Italy
    Genethon, 91002 Evry, France)

  • Mauro Giacca

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
    Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy)

  • Marina Lusic

    (Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
    Present addresses: Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg and German Center for Infection Research, 69120 Heidelberg, Germany (B.L.; M.L.); Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie (LNCIB), 34149 Trieste, Italy (K.L.); Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (L.M.); Pazmany University, Budapest 1083, Hungary (S.P.).)

Abstract

HIV-1 integration into the host cell genome occurs in the outer shell of the nucleus in close correspondence with the nuclear pore, in which a series of cellular genes are preferentially targeted by the virus.

Suggested Citation

  • Bruna Marini & Attila Kertesz-Farkas & Hashim Ali & Bojana Lucic & Kamil Lisek & Lara Manganaro & Sandor Pongor & Roberto Luzzati & Alessandra Recchia & Fulvio Mavilio & Mauro Giacca & Marina Lusic, 2015. "Nuclear architecture dictates HIV-1 integration site selection," Nature, Nature, vol. 521(7551), pages 227-231, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7551:d:10.1038_nature14226
    DOI: 10.1038/nature14226
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    Cited by:

    1. Hannah O. Ajoge & Tyler M. Renner & Kasandra Bélanger & Matthew Greig & Samar Dankar & Hinissan P. Kohio & Macon D. Coleman & Emmanuel Ndashimye & Eric J. Arts & Marc-André Langlois & Stephen D. Barr, 2023. "Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Monica Naughtin & Zofia Haftek-Terreau & Johan Xavier & Sam Meyer & Maud Silvain & Yan Jaszczyszyn & Nicolas Levy & Vincent Miele & Mohamed Salah Benleulmi & Marc Ruff & Vincent Parissi & Cédric Vaill, 2015. "DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-28, June.

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