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YAP is essential for tissue tension to ensure vertebrate 3D body shape

Author

Listed:
  • Sean Porazinski

    (University of Bath, Bath BA2 7AY, UK)

  • Huijia Wang

    (University of Bath, Bath BA2 7AY, UK)

  • Yoichi Asaoka

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan)

  • Martin Behrndt

    (IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria)

  • Tatsuo Miyamoto

    (Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan)

  • Hitoshi Morita

    (IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria)

  • Shoji Hata

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan)

  • Takashi Sasaki

    (School of Medicine, Keio University, Tokyo 160-8582, Japan)

  • S. F. Gabriel Krens

    (IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria)

  • Yumi Osada

    (Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan)

  • Satoshi Asaka

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan)

  • Akihiro Momoi

    (Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan)

  • Sarah Linton

    (University of Bath, Bath BA2 7AY, UK)

  • Joel B. Miesfeld

    (Neurobiology, and Anatomy, Medical College of Wisconsin)

  • Brian A. Link

    (Neurobiology, and Anatomy, Medical College of Wisconsin)

  • Takeshi Senga

    (Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan)

  • Atahualpa Castillo-Morales

    (University of Bath, Bath BA2 7AY, UK)

  • Araxi O. Urrutia

    (University of Bath, Bath BA2 7AY, UK)

  • Nobuyoshi Shimizu

    (School of Medicine, Keio University, Tokyo 160-8582, Japan)

  • Hideaki Nagase

    (Kennedy Institute of Rheumatology, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK)

  • Shinya Matsuura

    (Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan)

  • Stefan Bagby

    (University of Bath, Bath BA2 7AY, UK)

  • Hisato Kondoh

    (Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan
    Graduate School of Frontier Bioscience, Osaka University, Osaka 565-0871, Japan
    Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan)

  • Hiroshi Nishina

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan)

  • Carl-Philipp Heisenberg

    (IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria)

  • Makoto Furutani-Seiki

    (University of Bath, Bath BA2 7AY, UK
    Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan)

Abstract

D’Arcy Thompson predicted a century ago that animal body shape is conditioned by gravity, but there has been no animal model to study how cellular forces are coordinated to generate body shapes that withstand gravity; the hirame medaka fish mutant, with pronounced body flattening, reveals how the hirame/YAP gene controls gravity-resisting cellular forces to produce complex 3D organs and body shapes.

Suggested Citation

  • Sean Porazinski & Huijia Wang & Yoichi Asaoka & Martin Behrndt & Tatsuo Miyamoto & Hitoshi Morita & Shoji Hata & Takashi Sasaki & S. F. Gabriel Krens & Yumi Osada & Satoshi Asaka & Akihiro Momoi & Sar, 2015. "YAP is essential for tissue tension to ensure vertebrate 3D body shape," Nature, Nature, vol. 521(7551), pages 217-221, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7551:d:10.1038_nature14215
    DOI: 10.1038/nature14215
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    Cited by:

    1. Chrystian Junqueira Alves & Rafael Dariolli & Jonathan Haydak & Sangjo Kang & Theodore Hannah & Robert J. Wiener & Stefanie DeFronzo & Rut Tejero & Gabriele L. Gusella & Aarthi Ramakrishnan & Rodrigo , 2021. "Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion," Nature Communications, Nature, vol. 12(1), pages 1-23, December.
    2. Kazunori Sunadome & Alek G. Erickson & Delf Kah & Ben Fabry & Csaba Adori & Polina Kameneva & Louis Faure & Shigeaki Kanatani & Marketa Kaucka & Ivar Dehnisch Ellström & Marketa Tesarova & Tomas Zikmu, 2023. "Directionality of developing skeletal muscles is set by mechanical forces," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    3. Ana Sousa-Ortega & Javier Vázquez-Marín & Estefanía Sanabria-Reinoso & Jorge Corbacho & Rocío Polvillo & Alejandro Campoy-López & Lorena Buono & Felix Loosli & María Almuedo-Castillo & Juan R. Martíne, 2023. "A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Ngoc Minh Nguyen & Emmanuel Farge, 2024. "Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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