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Clinical improvement in psoriasis with specific targeting of interleukin-23

Author

Listed:
  • Tamara Kopp

    (Allergy and Infectious Diseases, University of Vienna Medical School
    Juvenis Medical Center)

  • Elisabeth Riedl

    (University of Vienna Medical School)

  • Christine Bangert

    (Allergy and Infectious Diseases, University of Vienna Medical School)

  • Edward P. Bowman

    (Merck & Co., Inc.)

  • Elli Greisenegger

    (Allergy and Infectious Diseases, University of Vienna Medical School)

  • Ann Horowitz

    (Merck & Co., Inc.)

  • Harald Kittler

    (University of Vienna Medical School)

  • Wendy M. Blumenschein

    (Merck & Co., Inc.)

  • Terrill K. McClanahan

    (Merck & Co., Inc.)

  • Thomas Marbury

    (Orlando Clinical Research Center)

  • Claus Zachariae

    (Gentofte Hospital, University of Copenhagen, Kildegaardsvej 28, DK-2900 Hellerup, Denmark)

  • Danlin Xu

    (Merck & Co., Inc.)

  • Xiaoli Shirley Hou

    (Merck & Co., Inc.)

  • Anish Mehta

    (Merck & Co., Inc.)

  • Anthe S. Zandvliet

    (Merck & Co., Inc.)

  • Diana Montgomery

    (Merck & Co., Inc.)

  • Frank van Aarle

    (Merck & Co., Inc.)

  • Sauzanne Khalilieh

    (Merck & Co., Inc.)

Abstract

A proof-of-concept phase I clinical trial demonstrates that targeting interleukin (IL)-23 with an antibody that binds to the p19 subunit leads to clinical improvement of disease in patients with moderate to severe psoriasis.

Suggested Citation

  • Tamara Kopp & Elisabeth Riedl & Christine Bangert & Edward P. Bowman & Elli Greisenegger & Ann Horowitz & Harald Kittler & Wendy M. Blumenschein & Terrill K. McClanahan & Thomas Marbury & Claus Zachar, 2015. "Clinical improvement in psoriasis with specific targeting of interleukin-23," Nature, Nature, vol. 521(7551), pages 222-226, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7551:d:10.1038_nature14175
    DOI: 10.1038/nature14175
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    Cited by:

    1. Chelisa Cardinez & Yuwei Hao & Kristy Kwong & Ainsley R. Davies & Morgan B. Downes & Nadia A. Roberts & Jason D. Price & Raquel A. Hernandez & Jessica Lovell & Rochna Chand & Zhi-Ping Feng & Anselm En, 2024. "IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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