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Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity

Author

Listed:
  • Yaron Carmi

    (School of Medicine, Stanford University)

  • Matthew H. Spitzer

    (School of Medicine, Stanford University
    School of Medicine, Baxter Laboratory in Stem Cell Biology, Stanford University)

  • Ian L. Linde

    (School of Medicine, Stanford University)

  • Bryan M. Burt

    (School of Medicine, Stanford University)

  • Tyler R. Prestwood

    (School of Medicine, Stanford University)

  • Nicola Perlman

    (School of Medicine, Stanford University)

  • Matthew G. Davidson

    (School of Medicine, Stanford University)

  • Justin A. Kenkel

    (School of Medicine, Stanford University)

  • Ehud Segal

    (School of Medicine, Stanford University)

  • Ganesh V. Pusapati

    (School of Medicine, Stanford University)

  • Nupur Bhattacharya

    (School of Medicine, Stanford University)

  • Edgar G. Engleman

    (School of Medicine, Stanford University)

Abstract

Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour immune complexes into dendritic cells activates tumour-reactive T cells, and intra-tumoral injection of allogeneic IgG together with dendritic cell adjuvants induces systemic T-cell-mediated antitumour responses.

Suggested Citation

  • Yaron Carmi & Matthew H. Spitzer & Ian L. Linde & Bryan M. Burt & Tyler R. Prestwood & Nicola Perlman & Matthew G. Davidson & Justin A. Kenkel & Ehud Segal & Ganesh V. Pusapati & Nupur Bhattacharya & , 2015. "Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity," Nature, Nature, vol. 521(7550), pages 99-104, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7550:d:10.1038_nature14424
    DOI: 10.1038/nature14424
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    Cited by:

    1. Thillai V. Sekar & Eslam A. Elghonaimy & Katy L. Swancutt & Sebastian Diegeler & Isaac Gonzalez & Cassandra Hamilton & Peter Q. Leung & Jens Meiler & Cristina E. Martina & Michael Whitney & Todd A. Ag, 2023. "Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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