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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

Author

Listed:
  • Shabnam Shalapour

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Joan Font-Burgada

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Giuseppe Di Caro

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Zhenyu Zhong

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Elsa Sanchez-Lopez

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Debanjan Dhar

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Gerald Willimsky

    (Institute of Immunology, Charité Campus Buch)

  • Massimo Ammirante

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Amy Strasner

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

  • Donna E. Hansel

    (School of Medicine, University of California San Diego)

  • Christina Jamieson

    (University of California San Diego)

  • Christopher J. Kane

    (University of California San Diego)

  • Tobias Klatte

    (Medical University of Vienna)

  • Peter Birner

    (Medical University of Vienna)

  • Lukas Kenner

    (Medical University of Vienna
    Clinical Institute of Pathology, Ludwig Boltzmann Institute for Cancer Research, Medical University of Vienna, Unit of Pathology of Laboratory Animals (UPLA), University of Veterinary Medicine Vienna)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
    School of Medicine, University of California San Diego)

Abstract

IgA plasmocytes are shown to promote resistance to the immunogenic chemotherapeutic oxaliplatin in prostate cancer mouse models by inhibiting activation of cytotoxic T cells; immunosuppressive plasma cells, which are also found in human-therapy-resistant prostate cancer, are generated in response to TGFβ, and their functionality depends on PD-L1 expression and IL-10 secretion.

Suggested Citation

  • Shabnam Shalapour & Joan Font-Burgada & Giuseppe Di Caro & Zhenyu Zhong & Elsa Sanchez-Lopez & Debanjan Dhar & Gerald Willimsky & Massimo Ammirante & Amy Strasner & Donna E. Hansel & Christina Jamieso, 2015. "Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy," Nature, Nature, vol. 521(7550), pages 94-98, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7550:d:10.1038_nature14395
    DOI: 10.1038/nature14395
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    Cited by:

    1. S. Shankar & J. Stolp & S. C. Juvet & J. Beckett & P. S. Macklin & F. Issa & J. Hester & K. J. Wood, 2022. "Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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