IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v521y2015i7550d10.1038_nature14179.html
   My bibliography  Save this article

A direct GABAergic output from the basal ganglia to frontal cortex

Author

Listed:
  • Arpiar Saunders

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Ian A. Oldenburg

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Vladimir K. Berezovskii

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Caroline A. Johnson

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Nathan D. Kingery

    (Neurobiology Imaging Facility, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Hunter L. Elliott

    (Image and Data Analysis Core, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Tiao Xie

    (Image and Data Analysis Core, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Charles R. Gerfen

    (Laboratory of Systems Neuroscience, National Institute of Mental Health)

  • Bernardo L. Sabatini

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

Abstract

Anatomical and functional analyses reveal the existence of two types of globus pallidus externus neurons that directly control cortex, suggesting a pathway by which dopaminergic drugs used to treat neuropsychiatric disorders may act in the basal ganglia to modulate cortex.

Suggested Citation

  • Arpiar Saunders & Ian A. Oldenburg & Vladimir K. Berezovskii & Caroline A. Johnson & Nathan D. Kingery & Hunter L. Elliott & Tiao Xie & Charles R. Gerfen & Bernardo L. Sabatini, 2015. "A direct GABAergic output from the basal ganglia to frontal cortex," Nature, Nature, vol. 521(7550), pages 85-89, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7550:d:10.1038_nature14179
    DOI: 10.1038/nature14179
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14179
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14179?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marie A. Labouesse & Arturo Torres-Herraez & Muhammad O. Chohan & Joseph M. Villarin & Julia Greenwald & Xiaoxiao Sun & Mysarah Zahran & Alice Tang & Sherry Lam & Jeremy Veenstra-VanderWeele & Clay O., 2023. "A non-canonical striatopallidal Go pathway that supports motor control," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Wang, Zhizhi & Hu, Bing & Zhou, Weiting & Xu, Minbo & Wang, Dingjiang, 2023. "Hopf bifurcation mechanism analysis in an improved cortex-basal ganglia network with distributed delays: An application to Parkinson’s disease," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).
    3. Nicola Montemurro & Nelida Aliaga & Pablo Graff & Amanda Escribano & Jafeth Lizana, 2022. "New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review," IJERPH, MDPI, vol. 19(14), pages 1-18, July.
    4. Sean C. Piantadosi & Elizabeth E. Manning & Brittany L. Chamberlain & James Hyde & Zoe LaPalombara & Nicholas M. Bannon & Jamie L. Pierson & Vijay M. K Namboodiri & Susanne E. Ahmari, 2024. "Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:521:y:2015:i:7550:d:10.1038_nature14179. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.