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X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

Author

Listed:
  • Kristina Haslinger

    (Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Madeleine Peschke

    (Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Clara Brieke

    (Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Egle Maximowitsch

    (Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Max J. Cryle

    (Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany)

Abstract

Glycopeptide antibiotics are biosynthesized by non-ribosomal peptide synthetases, which contain a previously uncharacterized ‘X-domain’ now shown to recruit three cytochrome P450 oxygenases that are necessary for the antibiotics to achieve their final, active conformation.

Suggested Citation

  • Kristina Haslinger & Madeleine Peschke & Clara Brieke & Egle Maximowitsch & Max J. Cryle, 2015. "X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis," Nature, Nature, vol. 521(7550), pages 105-109, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7550:d:10.1038_nature14141
    DOI: 10.1038/nature14141
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    Cited by:

    1. Hong Jie Zhu & Bo Zhang & Wanqing Wei & Shuang He Liu & Lang Xiang & Jiapeng Zhu & Rui Hua Jiao & Yasuhiro Igarashi & Ghader Bashiri & Yong Liang & Ren Xiang Tan & Hui Ming Ge, 2022. "AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Guifa Zhai & Yan Zhu & Guo Sun & Fan Zhou & Yangning Sun & Zhou Hong & Chuan Dong & Peter F. Leadlay & Kui Hong & Zixin Deng & Fuling Zhou & Yuhui Sun, 2023. "Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Mathias H. Hansen & Martina Adamek & Dumitrita Iftime & Daniel Petras & Frauke Schuseil & Stephanie Grond & Evi Stegmann & Max J. Cryle & Nadine Ziemert, 2023. "Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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